Selected pharmacokinetic issues in patients with chronic kidney disease

被引：5
作者：
Churchwell, Mariann D.
Mueller, Bruce A.
机构：
[1] Univ Michigan, Dept Clin Serv, Coll Pharm, Ann Arbor, MI 48109 USA
[2] Univ Toledo, Coll Pharm, Dept Pharm Practice, Toledo, OH 43606 USA
[3] Univ Michigan, Renal Replacement Therapy Kinet Study Grp, Ann Arbor, MI 48109 USA
来源：
BLOOD PURIFICATION | 2007年 / 25卷 / 01期
关键词：
pharmacotherapy; chronic kidney disease; pharmacokinetics;
D O I：
10.1159/000096412
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pharmacotherapy plays an important role in the care of a chronic kidney disease ( CKD) patient but delivering this therapy can be challenging. Besides alterations in the pharmacokinetic parameters of absorption, distribution, metabolism and elimination, the average CKD patient must take multiple medications each day. The likelihood of an adverse drug reaction increases with each medication added to these patients' daily regimen. In this article we discuss selected pharmacokinetic issues unique to CKD patients. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码：133 / 138
页数：6
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