Association of monocyte chemoattractant protein-1-2518A/G polymorphism and risk of coronary artery disease among the Chinese population: a meta-analysis

Background: Numerous studies have evaluated the association between the MCP-1-2518A/G polymorphism and coronary artery disease (CAD) risk; however, the actual association is controversial. To derive a more precise estimation of the relationship in Chinese population, we performed this meta-analysis. Methods: We searched the PubMed, Embase, Web of Science, and CNKI databases to identify studies that examined the association between the MCP-1-2518A/Gpolymorphism and the risk of CAD. We estimated the pooled odds ratio with its 95% confidence interval to assess this association. Results: Seven studies containing 4024 Chinese subjects (2260 patients with CAD and 1764 controls) were included in this meta-analysis. MCP-1-2518A/G polymorphism was not found to be significantly associated with CAD risk in all comparisons (for G vs A: OR=1.10, 95% CI=0.92-1.32; for AG+GG vs AA: OR=1.10, 95% CI=0.79-1.53; for GG vs AA+AG: OR=1.05, 95% CI=0.91-1.21; for GG vs AA: OR=1.12, 95% CI=0.82-1.54; for AG vs AA: OR=1.05, 95% CI=0.76-1.47). Similarly, no associations were found in subgroup analysis based on source of control and endpoint. Conclusions: the MCP-1-2518A/G polymorphism was not associated with the risk of CAD in Chinese population.