Modification of benzo(a)pyrene-induced blastomogenesis in rats by formaldehyde

This article presents data on carcinogenesis study following combined administration of the various benzo(a)pyrene (BP) doses (0.02-5.0 mg) and formaldehyde gases (FA) concentrations (0.0030.3mg/ m(3)) into respiratory organs of white rats. A modifying influence of formaldehyde on the carcinogenesis and its dependance on the dose has been found. Simultaneous exposure to BP at the dose of 5.0 mg with FA at the concentration of 0.3 mg/m(3) produces maximal carcinogenic effect reflected in the incidence, degree of malignancy, metastasizing activity, primarily multiple damages of various organs and localization spectre. Simultaneous exposure to BP and FA at the levels of their maximal permissible concentration (MPC) in the atmospheric air had no effect on spontaneous carcinogenesis.