The epigenomics of cancer

被引：3619

作者：

Jones, Peter A. ^{[1
]}

Baylin, Stephen B.

机构：

[1] Univ So Calif, Dept Urol Biochem & Mol Biol, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90089 USA

[2] Johns Hopkins Med Inst, Canc Biol Program, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.01.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer. © 2007 Elsevier Inc. All rights reserved.

引用

页码：683 / 692

页数：10

共 90 条

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