Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution

被引：18
作者：
Weis, J.
Johansson, L.
Courivaud, F.
Karlsson, F. A.
Ahlstrom, H.
机构：
[1] Univ Uppsala Hosp, Dept Radiol, MR Unit, SE-75185 Uppsala, Sweden
[2] Univ Uppsala Hosp, Dept Med Informat & Bioengn, SE-75185 Uppsala, Sweden
[3] Univ Uppsala Hosp, Astra Zeneca R&D, SE-75185 Uppsala, Sweden
[4] Philips Med Syst, Oslo, Norway
[5] Univ Uppsala Hosp, Dept Med Sci, SE-75185 Uppsala, Sweden
来源：
MAGNETIC RESONANCE IN MEDICINE | 2007年 / 57卷 / 01期
关键词：
obesity; intramyocellular lipids; spectroscopic imaging; skeletal muscle; quantitation; MAGNETIC-RESONANCE-SPECTROSCOPY; INSULIN SENSITIVITY; SKELETAL-MUSCLE; TRIGLYCERIDE CONTENT; LOWER LEG; FAT; RESISTANCE; HUMANS; MUSCULATURE; EXERCISE;
D O I：
10.1002/mrm.21085
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Quantification of intramyocellular lipids (IMCL) in obese subjects by single-voxel spectroscopy (SVS) or conventional spectroscopic imaging (SI) often fails due to overlap of IMCL spectral lines by extra myocellular lipids (EMCL), and signal contamination from subcutaneous fat and bone marrow. This study demonstrates that these problems can be solved by high-resolution SI with 128 phase-encoding steps and a read gradient during acquisition. The small voxels obtained in this way facilitated differentiation between EMCL and IMCL. This method offers the possibility of studying different muscle groups and the variation of lipids within one muscle.
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收藏
页码：22 / 28
页数：7
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