PIDA-induced oxidative C-N bond coupling of quinoxalinones and azoles

被引：14

作者：

Wimonsong, Watchara ^{[1
,2
]}

Yotphan, Sirilata ^{[1
,2
]}

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Rama VI Rd, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem, Rama VI Rd, Bangkok 10400, Thailand

来源：

TETRAHEDRON | 2021年 / 81卷

关键词：

Quinoxalinone; Azole; Metal-free; Oxidative coupling; PIDA; H AMINATION; IN-VITRO; QUINOXALIN-2(1H)-ONES; ARYLATION; DERIVATIVES; DESIGN; MILD; INHIBITORS; CHEMISTRY; DISCOVERY;

D O I：

10.1016/j.tet.2020.131919

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free promoted direct oxidative C-N bond coupling of quinoxalinones and azoles for the rapid and effective synthesis of potent pharmaceutical important 3-(azol-1-yl)quinoxalin-2-one has been developed. Employing PIDA as the easily available mediator, the desired coupling products were isolated in moderate to excellent yields with a good substrate scope under operational simplicity and mild reaction conditions. Preliminary mechanistic studies suggested that a radical process is likely to be involved in the reaction. (C) 2020 Elsevier Ltd. All rights reserved.

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页数：8

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