PIDA-induced oxidative C-N bond coupling of quinoxalinones and azoles

被引：14
|
作者：
Wimonsong, Watchara [1 ,2 ]
Yotphan, Sirilata [1 ,2 ]
机构：
[1] Mahidol Univ, Fac Sci, Dept Chem, Rama VI Rd, Bangkok 10400, Thailand
[2] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem, Rama VI Rd, Bangkok 10400, Thailand
来源：
TETRAHEDRON | 2021年 / 81卷
关键词：
Quinoxalinone; Azole; Metal-free; Oxidative coupling; PIDA; H AMINATION; IN-VITRO; QUINOXALIN-2(1H)-ONES; ARYLATION; DERIVATIVES; DESIGN; MILD; INHIBITORS; CHEMISTRY; DISCOVERY;
D O I：
10.1016/j.tet.2020.131919
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free promoted direct oxidative C-N bond coupling of quinoxalinones and azoles for the rapid and effective synthesis of potent pharmaceutical important 3-(azol-1-yl)quinoxalin-2-one has been developed. Employing PIDA as the easily available mediator, the desired coupling products were isolated in moderate to excellent yields with a good substrate scope under operational simplicity and mild reaction conditions. Preliminary mechanistic studies suggested that a radical process is likely to be involved in the reaction. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：8
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