Gastroprotective flavonoid constituents from Oroxylum indicum Vent.

被引：67

作者：

Babu, T. Hari ^{[1
]}

Manjulatha, K. ^{[2
]}

Kumar, G. Suresh ^{[1
]}

Hymavathi, A. ^{[1
]}

Tiwari, Ashok K. ^{[3
]}

Purohit, Muraleedhar ^{[2
]}

Rao, J. Madhusudana ^{[1
]}

Babu, K. Suresh ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Nat Prod Lab, Hyderabad 500607, Andhra Pradesh, India

[2] Univ Gulbarga, Dept Pharmaceut Chem, Gulbarga, India

[3] Indian Inst Chem Technol, Div Pharmacol, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 01期

关键词：

Oroxylum indicum; Bignoniaceae; Flavonoid glycosides; Anti gastric ulcer activity; RATS;

D O I：

10.1016/j.bmcl.2009.11.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation of the stem bark of Oroxylum indicum resulted in the isolation and characterization of two new. avonoid glycosides (1, 2), along with seven known compounds (3-9). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by the comparison with spectroscopic data reported in the literature. In addition, all the compounds were tested for their ulcer protective effects against various gastric ulceritis inducing models in rats. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：117 / 120

页数：4