Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array

被引：25

作者：

Zhang, Huakun ^{[1
,2
,4
]}

Ma, Haiqing ^{[1
,2
]}

Wang, Qujing ^{[1
,2
]}

Chen, Minshan ^{[3
]}

Weng, Desheng ^{[1
,2
]}

Wang, Hui ^{[1
,2
]}

Zhou, Jun ^{[1
,2
]}

Li, Yongqiang ^{[1
,2
]}

Sun, Jiancong ^{[1
,2
]}

Chen, Yibing ^{[1
,2
]}

Liang, Xiaoting ^{[1
,2
]}

Zhao, Jingjing ^{[1
,2
]}

Pan, Ke ^{[1
,2
]}

Wang, Huiyun ^{[1
,2
]}

Xia, Jianchuan ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, Guangzhou 510060, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Ctr Canc, Dept Hepatobilary Oncol, Guangzhou 510060, Guangdong, Peoples R China

[4] Shenzhen Matern & Child Healthcare Hosp, Cent Lab, Shenzhen 518033, Guangdong, Peoples R China

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 02期

关键词：

hepatocellular carcinoma; loss of heterozygosity; single nucleotide polymorphism; tumour suppressor gene; CANDIDATE TUMOR-SUPPRESSOR; SQUAMOUS-CELL CARCINOMA; GENETIC ALTERATIONS; TRANSCRIPTION FACTORS; REGULATORY ELEMENTS; PRIMER EXTENSION; FREQUENT LOSS; HOST-DEFENSE; DNA-DAMAGE; REGION;

D O I：

10.3892/or_00000654

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To identify tumour suppressor genes (TSGs) associated with hepatocellular carcinoma (HCC) on chromosome 4q using a high-throughput single nucleotide polymorphism (SNP) array, we first scanned for loss of heterozygosity (LOH) of 40 SNPs on chromosome 4q and discovered 2 hot regions: 4q24-26 and 4q34.3-35. We then further scanned for LOH of 338 SNPs in genes around 4q34.3-35 and discovered 3 genes with the most frequent LOH: nei endonuclease VIII-like 3 (NEIL3), interferon regulatory factor 2 (IRF2) and inhibitor of growth family member 2 (ING2). A review of the literature indicates only ING2 might be a TSG associated with HCC.

引用

页码：445 / 455

页数：11

共 31 条

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Li, Jing
Ma, Mengqing
Lv, Minling
Hu, Rui
Sun, Jialing
Zhong, Xin
Sun, Xinfeng
Feng, Wenxing
Ma, Wenfeng
Zhang, Wei
Zhan, Bolin
Han, Zhiyi
Zhou, Xiaozhou
INTERNATIONAL JOURNAL OF ONCOLOGY, 2023, 62 (03)

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