Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array

被引：25
|
作者：
Zhang, Huakun [1 ,2 ,4 ]
Ma, Haiqing [1 ,2 ]
Wang, Qujing [1 ,2 ]
Chen, Minshan [3 ]
Weng, Desheng [1 ,2 ]
Wang, Hui [1 ,2 ]
Zhou, Jun [1 ,2 ]
Li, Yongqiang [1 ,2 ]
Sun, Jiancong [1 ,2 ]
Chen, Yibing [1 ,2 ]
Liang, Xiaoting [1 ,2 ]
Zhao, Jingjing [1 ,2 ]
Pan, Ke [1 ,2 ]
Wang, Huiyun [1 ,2 ]
Xia, Jianchuan [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, Guangzhou 510060, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, Dept Hepatobilary Oncol, Guangzhou 510060, Guangdong, Peoples R China
[4] Shenzhen Matern & Child Healthcare Hosp, Cent Lab, Shenzhen 518033, Guangdong, Peoples R China
来源：
ONCOLOGY REPORTS | 2010年 / 23卷 / 02期
关键词：
hepatocellular carcinoma; loss of heterozygosity; single nucleotide polymorphism; tumour suppressor gene; CANDIDATE TUMOR-SUPPRESSOR; SQUAMOUS-CELL CARCINOMA; GENETIC ALTERATIONS; TRANSCRIPTION FACTORS; REGULATORY ELEMENTS; PRIMER EXTENSION; FREQUENT LOSS; HOST-DEFENSE; DNA-DAMAGE; REGION;
D O I：
10.3892/or_00000654
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To identify tumour suppressor genes (TSGs) associated with hepatocellular carcinoma (HCC) on chromosome 4q using a high-throughput single nucleotide polymorphism (SNP) array, we first scanned for loss of heterozygosity (LOH) of 40 SNPs on chromosome 4q and discovered 2 hot regions: 4q24-26 and 4q34.3-35. We then further scanned for LOH of 338 SNPs in genes around 4q34.3-35 and discovered 3 genes with the most frequent LOH: nei endonuclease VIII-like 3 (NEIL3), interferon regulatory factor 2 (IRF2) and inhibitor of growth family member 2 (ING2). A review of the literature indicates only ING2 might be a TSG associated with HCC.
引用
收藏
页码：445 / 455
页数：11
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