Induction of homosynaptic long-term depression in entorhinal cortex

被引：11
作者：
Cheong, MY
Yun, SH
Mook-Jung, I
Kang, Y
Jung, MW [1 ]
机构：
[1] Ajou Univ, Neurosci Lab, Inst Med Sci, Sch Med, Suwon 442721, South Korea
[2] Ajou Univ, Brain Dis Res Ctr, Sch Med, Suwon 442721, South Korea
来源：
BRAIN RESEARCH | 2002年 / 954卷 / 02期
关键词：
long-term depression; entorhinal cortex; hippocampus; rat brain; brain slice;
D O I：
10.1016/S0006-8993(02)03516-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Prolonged low frequency stimulation (1 Hz, 15 min) induced significant long-term depression (LTD) in hippocampal CA1 region and superficial, but not deep, layers of rat medial entorhinal cortex (EC) in vitro. In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：308 / 310
页数：3
相关论文
共 12 条
[1]   POSTSYNAPTIC HEBBIAN AND NON-HEBBIAN LONG-TERM POTENTIATION OF SYNAPTIC EFFICACY IN THE ENTORHINAL CORTEX IN SLICES AND IN THE ISOLATED ADULT GUINEA-PIG BRAIN [J].
ALONSO, A ;
DECURTIS, M ;
LLINAS, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (23) :9280-9284
[2]  
Amaral David G., 1995, P443
[3]   Cholinergic modulation of synaptic physiology in deep layer entorhinal cortex of the rat [J].
Cheong, MY ;
Yun, SH ;
Mook-Jung, I ;
Joo, I ;
Huh, K ;
Jung, MW .
JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 66 (01) :117-121
[4]   HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF HIPPOCAMPUS AND EFFECTS OF N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE [J].
DUDEK, SM ;
BEAR, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4363-4367
[5]   WHY THERE ARE COMPLEMENTARY LEARNING-SYSTEMS IN THE HIPPOCAMPUS AND NEOCORTEX - INSIGHTS FROM THE SUCCESSES AND FAILURES OF CONNECTIONIST MODELS OF LEARNING AND MEMORY [J].
MCCLELLAND, JL ;
MCNAUGHTON, BL ;
OREILLY, RC .
PSYCHOLOGICAL REVIEW, 1995, 102 (03) :419-457
[6]   MECHANISMS UNDERLYING INDUCTION OF HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF THE HIPPOCAMPUS [J].
MULKEY, RM ;
MALENKA, RC .
NEURON, 1992, 9 (05) :967-975
[7]   LONG-TERM POTENTIATION PHENOMENA IN THE RAT LIMBIC FOREBRAIN [J].
RACINE, RJ ;
MILGRAM, NW ;
HAFNER, S .
BRAIN RESEARCH, 1983, 260 (02) :217-231
[8]   MEMORY AND THE HIPPOCAMPUS - A SYNTHESIS FROM FINDINGS WITH RATS, MONKEYS, AND HUMANS [J].
SQUIRE, LR .
PSYCHOLOGICAL REVIEW, 1992, 99 (02) :195-231
[9]   Variation in effective stimulus patterns for induction of long-term potentiation across different layers of rat entorhinal cortex [J].
Yun, SH ;
Mook-Jung, I ;
Jung, MW .
JOURNAL OF NEUROSCIENCE, 2002, 22 (05)
[10]  
Yun SH, 2000, SYNAPSE, V35, P1, DOI 10.1002/(SICI)1098-2396(200001)35:1<1::AID-SYN1>3.0.CO
12