Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis

被引：47

作者：

Mann, Francis M. ^{[1
]}

Xu, Meimei ^{[1
]}

Chen, Xiaoming ^{[1
]}

Fulton, D. Bruce ^{[1
]}

Russell, David G. ^{[2
]}

Peters, Reuben J. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA

[2] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 48期

关键词：

FUNCTIONAL-ANALYSIS; SYNTHASE;

D O I：

10.1021/ja9019287

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection. © 2009 American Chemical Society.

引用

页码：17526 / 17527

页数：2

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