The prognostic role of phospho-Src family kinase analysis in tongue cancer

被引：9
作者：
Ben-Izhak, Ofer [2 ]
Cohen-Kaplan, Victoria [3 ]
Nagler, Rafael M. [1 ]
机构：
[1] Technion Israel Inst Technol, Oral Biochem Lab, Dept Oral & Maxillofacial Surg, Rambam Med Ctr,Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
[2] Rambam Med Ctr, Dept Pathol, Haifa, Israel
[3] Technion Israel Inst Technol, Canc & Vasc Biol Res Ctr, Rappaport Fac Med, IL-31096 Haifa, Israel
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2010年 / 136卷 / 01期
关键词：
Phospho-Src family kinase; Oncogene; Tongue; Cancer; Tumor marker; Prognosis; C-SRC; INCREASING INCIDENCE; TUMOR-MARKERS; EXPRESSION; PHOSPHORYLATION; CARCINOMA; GROWTH; GENE; PROLIFERATION; APOPTOSIS;
D O I：
10.1007/s00432-009-0633-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The up regulation of Phospho-Src family kinase oncogene has been correlated with reduced post-operative survival in various cancers but never in tongue cancer. We analyzed phospho-Src family kinase in 39 tongue (mobile) cancer patients by immunohistochemistry, compared these results with similar analysis for TUNEL and c-erbB-2 and with both clinical tumor characteristics and patient survival probability rates. Phospho-Src family kinase overexpression was found in most tongue cancer biopsies (62%), significantly correlating with tumors larger in size (P = 0.05), progression-lymph node metastasis (0.004) and stage (P = 0.05), and correlating with TUNEL (P = 0.01) and c-erbB-2 (P = 0.05) expression rates. At 60 months, survival probability for negative phospho-Src family kinase level (=0) patients was 67%, but 30% for positive phospho-Src family kinase level (> 0) patients (P = 0.05). Inverse correlation between phospho-Src family kinase and patient survival demonstrates the prognostic role of phospho-Src family kinase in tongue cancer. These findings suggest a novel link between phospho-Src family kinase and TUNEL and c-erbB-2 pathways, tilting the balance toward cell proliferation.
引用
收藏
页码：27 / 34
页数：8
相关论文
共 44 条
[1]   THE PRODUCT OF THE HUMAN C-ERBB-2 GENE - A 185-KILODALTON GLYCOPROTEIN WITH TYROSINE KINASE-ACTIVITY [J].
AKIYAMA, T ;
SUDO, C ;
OGAWARA, H ;
TOYOSHIMA, K ;
YAMAMOTO, T .
SCIENCE, 1986, 232 (4758) :1644-1646
[2]  
Alho OP, 1999, ACTA ONCOL, V38, P1021
[3]   Novel insights into c-Src [J].
Alper, Ö ;
Bowden, ET .
CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (09) :1119-1130
[4]   The role of Src in solid and hematologic malignancies - Development of new-generation Src inhibitors [J].
Alvarez, Ricardo H. ;
Kantarjian, Hagop M. ;
Cortes, Jorge E. .
CANCER, 2006, 107 (08) :1918-1929
[5]   Salivary analysis in oral cancer patients - DNA and protein oxidation, reactive nitrogen species, and antioxidant profile [J].
Bahar, Gideon ;
Feinmesser, Raphael ;
Shpitzer, Thomas ;
Popovtzer, Aaron ;
Nagler, Rafael M. .
CANCER, 2007, 109 (01) :54-59
[6]   TUNEL - an efficient prognosis predictor of salivary malignancies [J].
Ben-Izhak, O. ;
Laster, Z. ;
Araidy, S. ;
Nagler, R. M. .
BRITISH JOURNAL OF CANCER, 2007, 96 (07) :1101-1106
[7]   Oropharyngeal cancer pathogenesis: Ubiquitin proteolytic, apoptotic and epidermal growth factor related pathways act in concert - first report [J].
Ben-Izhak, O ;
Kablan, F ;
Laster, Z ;
Nagler, RM .
ORAL ONCOLOGY, 2005, 41 (08) :851-860
[8]   Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival [J].
Ben-Izhak, Ofer ;
Kaplan-Cohen, Victoria ;
Ilan, Neta ;
Gan, Shlomit ;
Vlodavsky, Israel ;
Nagler, Rafael .
NEOPLASIA, 2006, 8 (10) :879-884
[9]   Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases [J].
Chong, YP ;
Ia, KK ;
Mulhern, TD ;
Cheng, HC .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2005, 1754 (1-2) :210-220
[10]   Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion [J].
Conway, William C. ;
van Zyp, Jochem Van der Voort ;
Thamilselvan, Vijayalakshmi ;
Walsh, Mary F. ;
Crowe, David L. ;
Basson, Marc D. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 98 (06) :1507-1516
12345