The toxic effect of different concentrations of povidone iodine on the rabbit's cornea

被引：98

作者：

Jiang, Jin ^{[1
,2
]}

Wu, Miaoqin ^{[1
]}

Shen, Ting ^{[1
]}

机构：

[1] Zhejiang Prov Peoples Hosp, Dept Ophthalmol, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Univ, Ctr Eye, Affiliated Hosp 2, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CUTANEOUS AND OCULAR TOXICOLOGY | 2009年 / 28卷 / 03期

关键词：

Polyvinylpyrrolidone iodine; povidone iodine; toxicity; cornea; antisepsis; OPHTHALMIC SURGERY; CHEMICAL PREPARATION; POLYVINYLPYRROLIDONE-IODINE; CATARACT-EXTRACTION; EYE; DISINFECTION; CONJUNCTIVA; EFFICACY;

D O I：

10.1080/15569520903080511

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objectives: To investigate the effects of polyvinylpyrrolidone (i.e., povidone) iodine (PVP-I) in different concentrations on the rabbit's cornea. Methods: PVP-I in various concentrations was instilled into the conjunctival sac and injected into the anterior chamber independently. The toxicity to the cornea was assessed by fluorescence dye, specular microscopy, and corneal pachymetry. Results: After conjunctival sac PVP-I instillation, severe epithelial damage was observed at the concentrations of 5.0% and 2.5%. After anterior chamber PVP-I injection, significant corneal edema was observed at the concentrations of 2.0% and 1.5%. Conclusions: It can be safe and feasible to use 0.5% or 1.0% concentrations of PVP-I in conjunctival sac instillation for preoperative antisepsis.

引用

页码：119 / 124

页数：6

共 21 条

[1] Nosocomial acute onset postoperative endophthalmitis survey - A 10-year review of incidence and outcomes [J].

Aaberg, TM ;

Flynn, HW ;

Schiffman, J ;

Newton, J .

OPHTHALMOLOGY, 1998, 105 (06) :1004-1010

[2] The effect of povidone iodine on the corneal endothelium [J].

Alp, BN ;

Elibol, O ;

Sargon, MF ;

Aslan, OS ;

Yanyali, A ;

Karabas, L ;

Talu, H ;

Caglar, Y .

CORNEA, 2000, 19 (04) :546-550

[3] ANTIMICROBIAL PREPARATION OF THE EYE FOR SURGERY [J].

APT, L ;

ISENBERG, SJ ;

YOSHIMORI, R .

JOURNAL OF HOSPITAL INFECTION, 1985, 6 :163-172

[4] CHEMICAL PREPARATION OF THE EYE IN OPHTHALMIC SURGERY .3. EFFECT OF POVIDONE-IODINE ON THE CONJUNCTIVA [J].

APT, L ;

ISENBERG, S ;

YOSHIMORI, R ;

PAEZ, JH .

ARCHIVES OF OPHTHALMOLOGY, 1984, 102 (05) :728-729

[5] THE EFFECT OF POVIDONE-IODINE SOLUTION APPLIED AT THE CONCLUSION OF OPHTHALMIC SURGERY [J].

APT, L ;

ISENBERG, SJ ;

YOSHIMORI, R ;

CHANG, A ;

LAM, GC ;

WACHLER, B ;

NEUMANN, D .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1995, 119 (06) :701-705

[6] THE SENSITIVITY OF NEISSERIA-GONORRHOEAE, CHLAMYDIA-TRACHOMATIS, AND HERPES-SIMPLEX TYPE-II TO DISINFECTION WITH POVIDONE-IODINE [J].

BENEVENTO, WJ ;

MURRAY, P ;

REED, CA ;

PEPOSE, JS .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1990, 109 (03) :329-333

[7]

CALDWELL DR, 1984, ANN OPHTHALMOL, V16, P577

[8] Bacterial endophthalmitis prophylaxis for cataract surgery -: An evidence-based update [J].

Ciulla, TA ;

Starr, MB ;

Masket, S .

OPHTHALMOLOGY, 2002, 109 (01) :13-24

[9] EFFECT OF POVIDONE-IODINE IRRIGATION ON THE PREOPERATIVE CHEMICAL PREPARATION OF THE EYE [J].

GRIMES, SR ;

WHIDDON, RG ;

HOLLSTEN, D ;

TREVINO, SB ;

NAUSCHUETZ, WF .

MILITARY MEDICINE, 1992, 157 (03) :111-113

[10]

Isenberg Sherwin J, 2003, Community Eye Health, V16, P30

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