Cell to cell communication by autoinducing peptides in gram-positive bacteria

被引:204
作者
Sturme, MHJ
Kleerebezem, M
Nakayama, J
Akkermans, ADL
Vaughan, EE
de Vos, WM
机构
[1] Univ Wageningen & Res Ctr, Microbiol Lab, NL-6703 CT Wageningen, Netherlands
[2] NIZO Food Res, NL-6710 BA Ede, Netherlands
[3] Wageningen Ctr Food Sci, Wageningen, Netherlands
[4] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Higashi Ku, Fukuoka 8128581, Japan
来源
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 2002年 / 81卷 / 1-4期
关键词
autoinducing peptides; Gram-positive bacteria; quorum sensing; two-component regulatory systems;
D O I
10.1023/A:1020522919555
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
While intercellular communication systems in Gram-negative bacteria are often based on homoserine lactones as signalling molecules, it has been shown that autoinducing peptides are involved in intercellular communication in Gram-positive bacteria. Many of these peptides are exported by dedicated systems, posttranslationally modified in various ways, and finally sensed by other cells via membrane-located receptors that are part of two-component regulatory systems. In this way the expression of a variety of functions including virulence, genetic competence and the production of antimicrobial compounds can be modulated in a co-ordinated and cell density- and growth phase-dependent manner. Occasionally the autoinducing peptide has a dual function, such as in the case of nisin that is both a signalling pheromone involved in quorum sensing and an antimicrobial peptide. Moreover, biochemical, genetic and genomic studies have shown that bacteria may contain multiple quorum sensing systems, underlining the importance of intercellular communication. Finally, in some cases different peptides may be recognised by the same receptor, while also hybrid receptors have been constructed that respond to new peptides or show novel responses. This paper provides an overview of the characteristics of autoinducing peptide-based quorum sensing systems, their application in various gram-positive bacteria, and the discovery of new systems in natural and engineered ecosystems.
引用
收藏
页码:233 / 243
页数:11
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