Diabetes Mellitus and Heart Failure

被引：183
作者：
Lehrke, Michael [1 ]
Marx, Nikolaus [1 ]
机构：
[1] Univ Hosp Aachen, Dept Internal Med 1, Pauwelsstr 30, D-52074 Aachen, Germany
来源：
AMERICAN JOURNAL OF MEDICINE | 2017年 / 130卷 / 06期
关键词：
Cardiac function; Ejection fraction; Heart failure; Sodium glucose cotransporter 2; Type 2 diabetes mellitus; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; 2013 ACCF/AHA GUIDELINE; INDEPENDENT RISK-FACTOR; ASSOCIATION TASK-FORCE; ALL-CAUSE MORTALITY; ATRIAL-FIBRILLATION; CARDIOVASCULAR OUTCOMES; GLUCOSE ABNORMALITIES; MYOCARDIAL-INFARCTION; CARDIAC METABOLISM;
D O I：
10.1016/j.amjmed.2017.04.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epidemiologic and clinical data from the last 2 decades have shown that the prevalence of heart failure in diabetes is very high, and the prognosis for patients with heart failure is worse in those with diabetes than in those without diabetes. Experimental data suggest that various mechanisms contribute to the impairment in systolic and diastolic function in patients with diabetes, and there is an increased recognition that these patients develop heart failure independent of the presence of coronary artery disease or its associated risk factors. In addition, current clinical data demonstrated that treatment with the sodium glucose cotransporter 2 inhibitor empagliflozin reduced hospitalization for heart failure in patients with type 2 diabetes mellitus and high cardiovascular risk. This review article summarizes recent data on the prevalence, prognosis, pathophysiology, and therapeutic strategies to treat patients with diabetes and heart failure. (C) 2017 The Authors. Published by Elsevier Inc.
引用
收藏
页码：S40 / S50
页数：11
相关论文
共 91 条
[71]   Associations of dipeptidyl peptidase-4 inhibitors with mortality in hospitalized heart failure patients with diabetes mellitus [J].
Sato, Akihiko ;
Yoshihisa, Akiomi ;
Kanno, Yuki ;
Takiguchi, Mai ;
Miura, Shunsuke ;
Shimizu, Takeshi ;
Nakamura, Yuichi ;
Yamauchi, Hiroyuki ;
Owada, Takashi ;
Sato, Takamasa ;
Suzuki, Satoshi ;
Oikawa, Masayoshi ;
Yamaki, Takayoshi ;
Sugimoto, Koichi ;
Kunii, Hiroyuki ;
Nakazato, Kazuhiko ;
Suzuki, Hitoshi ;
Saitoh, Shu-ichi ;
Takeishi, Yasuchika .
ESC HEART FAILURE, 2016, 3 (02) :77-85
[72]   Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial [J].
Scirica, Benjamin M. ;
Braunwald, Eugene ;
Raz, Itamar ;
Cavender, Matthew A. ;
Morrow, David A. ;
Jarolim, Petr ;
Udell, Jacob A. ;
Mosenzon, Ofri ;
Im, KyungAh ;
Umez-Eronini, Amarachi A. ;
Pollack, Pia S. ;
Hirshberg, Boaz ;
Frederich, Robert ;
Lewis, Basil S. ;
McGuire, Darren K. ;
Davidson, Jaime ;
Steg, Ph. Gabriel ;
Bhatt, Deepak L. .
CIRCULATION, 2014, 130 (18) :1579-+
[73]   Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus [J].
Scirica, Benjamin M. ;
Bhatt, Deepak L. ;
Braunwald, Eugene ;
Steg, P. Gabriel ;
Davidson, Jaime ;
Hirshberg, Boaz ;
Ohman, Peter ;
Frederich, Robert ;
Wiviott, Stephen D. ;
Hoffman, Elaine B. ;
Cavender, Matthew A. ;
Udell, Jacob A. ;
Desai, Nihar R. ;
Mosenzon, Ofri ;
McGuire, Darren K. ;
Ray, Kausik K. ;
Leiter, Lawrence A. ;
Raz, Itamar ;
Braunwald, Eugene ;
Bhatt, Deepak L. ;
Scirica, Benjamin M. ;
Udell, Jacob A. ;
Cavender, Matthew A. ;
Desai, Nihar ;
Abrahamsen, Timothy ;
Grossman, Michelle ;
Morin, Suzanne ;
Im, Kyungah ;
Hoffman, Elaine ;
Gabovitch, Daniel ;
Pricken, Alexandra ;
Mosenzon, Ofri ;
Buskila, Alona ;
Ohman, Peter ;
Hirshberg, Boaz ;
Stahre, Christina ;
Price, Deborah ;
Billing-Clason, Solveig ;
Sabel, Karin ;
Monyak, John ;
Sjostrand, Mikalea ;
Wei, Cheryl ;
Lu, Jane ;
Miller, Elinor ;
Raichlen, Joel ;
Fitt, Sandy ;
Frederich, Robert ;
Iqbal, Nayyar ;
Donovan, Mark ;
Davidson, Jaime A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (14) :1317-1326
[74]   Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes [J].
Shah, Manasi S. ;
Brownlee, Michael .
CIRCULATION RESEARCH, 2016, 118 (11) :1808-1829
[75]   Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents [J].
Shimizu, Ippei ;
Minamino, Tohru ;
Toko, Haruhiro ;
Okada, Sho ;
Ikeda, Hiroyuki ;
Yasuda, Noritaka ;
Tateno, Kaoru ;
Moriya, Junji ;
Yokoyama, Masataka ;
Nojima, Aika ;
Koh, Gou Young ;
Akazawa, Hiroshi ;
Shiojima, Ichiro ;
Kahn, C. Ronald ;
Abel, E. Dale ;
Komuro, Issei .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) :1506-1514
[76]   Insulin-treated dia betes is associated with a marked increase in mortality in patients with advanced heart failure [J].
Smooke, S ;
Horwich, TB ;
Fonarow, GC .
AMERICAN HEART JOURNAL, 2005, 149 (01) :168-174
[77]   Ventricular remodeling does not accompany the development of heart failure in diabetic patients after myocardial infarction [J].
Solomon, SD ;
Sutton, MS ;
Lamas, GA ;
Plappert, T ;
Rouleau, JL ;
Skali, H ;
Moyé, L ;
Braunwald, E ;
Pfeffer, MA .
CIRCULATION, 2002, 106 (10) :1251-1255
[78]   Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease [J].
Sverdlov, Aaron L. ;
Elezaby, Aly ;
Qin, Fuzhong ;
Behring, Jessica B. ;
Luptak, Ivan ;
Calamaras, Timothy D. ;
Siwik, Deborah A. ;
Miller, Edward J. ;
Liesa, Marc ;
Shirihai, Orian S. ;
Pimentel, David R. ;
Cohen, Richard A. ;
Bachschmid, Markus M. ;
Colucci, Wilson S. .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (01)
[79]   Glucose abnormalities and heart failure predict poor prognosis in the population-based Reykjavik Study [J].
Thrainsdottir, Inga S. ;
Aspelund, Thor ;
Hardarson, Thordur ;
MaImberg, Klas ;
Sigurdsson, Gunnar ;
Thorgeirsson, Gudmundur ;
Gudnason, Vilmundur ;
Ryden, Lars .
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, 2005, 12 (05) :465-471
[80]   The association between glucose abnormalities and heart failure in the population-based Reykjavik study [J].
Thrainsdottir, IS ;
Aspelund, T ;
Thorgeirsson, G ;
Gudnason, V ;
Hardarson, T ;
Malmberg, K ;
Sigurdsson, G ;
Rydén, L .
DIABETES CARE, 2005, 28 (03) :612-616
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