Diabetes Mellitus and Heart Failure

被引：183

作者：

Lehrke, Michael ^{[1
]}

Marx, Nikolaus ^{[1
]}

机构：

[1] Univ Hosp Aachen, Dept Internal Med 1, Pauwelsstr 30, D-52074 Aachen, Germany

来源：

AMERICAN JOURNAL OF MEDICINE | 2017年 / 130卷 / 06期

关键词：

Cardiac function; Ejection fraction; Heart failure; Sodium glucose cotransporter 2; Type 2 diabetes mellitus; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; 2013 ACCF/AHA GUIDELINE; INDEPENDENT RISK-FACTOR; ASSOCIATION TASK-FORCE; ALL-CAUSE MORTALITY; ATRIAL-FIBRILLATION; CARDIOVASCULAR OUTCOMES; GLUCOSE ABNORMALITIES; MYOCARDIAL-INFARCTION; CARDIAC METABOLISM;

D O I：

10.1016/j.amjmed.2017.04.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiologic and clinical data from the last 2 decades have shown that the prevalence of heart failure in diabetes is very high, and the prognosis for patients with heart failure is worse in those with diabetes than in those without diabetes. Experimental data suggest that various mechanisms contribute to the impairment in systolic and diastolic function in patients with diabetes, and there is an increased recognition that these patients develop heart failure independent of the presence of coronary artery disease or its associated risk factors. In addition, current clinical data demonstrated that treatment with the sodium glucose cotransporter 2 inhibitor empagliflozin reduced hospitalization for heart failure in patients with type 2 diabetes mellitus and high cardiovascular risk. This review article summarizes recent data on the prevalence, prognosis, pathophysiology, and therapeutic strategies to treat patients with diabetes and heart failure. (C) 2017 The Authors. Published by Elsevier Inc.

引用

页码：S40 / S50

页数：11

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