Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy

被引：27

作者：

Krause, AS ^{[1
]}

Weihrauch, MR ^{[1
]}

Bode, U ^{[1
]}

Fleischhack, G ^{[1
]}

Elter, T ^{[1
]}

Heuer, T ^{[1
]}

Engert, A ^{[1
]}

Diehl, V ^{[1
]}

Josting, A ^{[1
]}

机构：

[1] Univ Cologne, Dept Internal Med 1, Cologne, Germany

来源：

LEUKEMIA & LYMPHOMA | 2002年 / 43卷 / 11期

关键词：

MTX; carboxypeptidase; lymphoma; rescue;

D O I：

10.1080/1042819021000032953

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-dose methotrexate (RDMTX) is a component of many cancer treatment regimens. Despite careful management, delayed renal clearance, followed by extremely high serum levels with potentially life-threatening toxicity can occur. In the present study, we report our results of carboxypeptidase-G(2) (CPDG(2)) rescue in 8 patients with delayed methotrexate elimination and renal impairment after HDMTX therapy for lymphoma or osteosarcoma. A dose of 50U/kg CPDG2 was administered. MTX plasma levels decreased rapidly and recovery of renal function was observed in all patients. No patient developed severe WHO grade 4 MTX toxicity. CPDG2 provides an alternative route of MTX elimination by converting it to inactive and non-toxic metabolites. CPDG(2), rescue was well tolerated, safe and very effective in preventing severe or life-threatening MTX toxicity.

引用

页码：2139 / 2143

页数：5

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