Viral evasion of natural killer cells

被引：147

作者：

Orange, JS ^{[1
]}

Fassett, MS ^{[1
]}

Koopman, LA ^{[1
]}

Boyson, JE ^{[1
]}

Strominger, JL ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 11期

关键词：

D O I：

10.1038/ni1102-1006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses have evolved mechanisms to avoid the host immune system, including means of escaping detection by both the innate and adaptive immune responses. Natural killer (NK) cells are a central component of the innate immune system and are crucial in defense against certain viruses. To attain a state of chronic infection, some successful viruses have developed specific mechanisms to evade detection by and activation of NK cells. These NK cell-specific evasion mechanisms fall into distinct mechanistic categories used in numerous virus families.

引用

页码：1006 / 1012

页数：7

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