Comparison of amino acid sequences at the amino acid 130-160 region of VP1 polypeptide of Indian field isolates of foot-and-mouth disease virus serotype Asia 1

被引：0

作者：

Sanyal, A ^{[1
]}

Gurumurthy, CB ^{[1
]}

Venkataramanan, R ^{[1
]}

Hemadri, D ^{[1
]}

Tosh, C ^{[1
]}

机构：

[1] Indian Vet Res Inst, All India Coordinated Res Project Foot & Mouth Di, Cent Lab, Nainital 263138, UP, India

来源：

ACTA VIROLOGICA | 2000年 / 44卷 / 02期

关键词：

FMD virus; serotype Asia 1; Indian isolates; VP1; amino acid sequence; variability index;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide and deduced amino acid sequences in the amino acid (aa) 130-160 region of VPI polypeptide of 65 field isolates of foot-and mouth disease virus (FMDV) serotype Asia 1 were determined and the consensus sequences were deduced. Comparison of amino acid sequences revealed conservation of NGK (130-132), TYG (134-136), RGD (142-144), and LPTSF(156-160) motifs and aa 148 (L) while variation was observed at the rest of the region (variability index (VI) of 2.06 to 16.85). Synonymous and non-synonymous mutations at the nucleotide level were well correlated with those of the corresponding amino acids. Comparison of the aa 130-160 sequence of Asia I serotype with those of other serotypes of FMDV revealed conservation of aa 135, 148-149, 157 and 160. Amino acids 133-138 and 148-154 were unique for Asia 1 serotype and are presumably responsible for its distinct antigenic nature. The present study revealed that the FMDV isolates of serotype Asia 1 causing outbreaks in India are very much heterogeneous in the aa 130-160 region of VP1.

引用

页码：85 / 90

页数：6

共 26 条

[1] THE 3-DIMENSIONAL STRUCTURE OF FOOT-AND-MOUTH-DISEASE VIRUS AT 2.9-A RESOLUTION [J].