Flavonoid identification and hypoglycaemic studies of the butanol fraction from Gynura procumbens

被引：101

作者：

Akowuah, GA ^{[1
]}

Sadikun, A ^{[1
]}

Mariam, A ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town, Malaysia

来源：

PHARMACEUTICAL BIOLOGY | 2002年 / 40卷 / 06期

关键词：

streptozotocin; glibenclamide; Compositae; flavonoid glycoside; kaempferol; quercetin;

D O I：

10.1076/phbi.40.6.405.8440

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and n-butanol. Qualitative HPLC identification of the major flavonoid constituents in the n-butanol fraction and separation of standard mixture of isolated compounds from the n-butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n-butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats.

引用

页码：405 / 410

页数：6

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