Splitting the chromosome: Cutting the ties that bind sister chromatids

被引：362
作者：
Nasmyth, K [1 ]
Peters, LM [1 ]
Uhlmann, F [1 ]
机构：
[1] Res Inst Mol Pathol, A-1030 Vienna, Austria
来源：
SCIENCE | 2000年 / 288卷 / 5470期
关键词：
D O I：
10.1126/science.288.5470.1379
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase,
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页码：1379 / 1384
页数：6
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