A facile synthesis of 7-amino-3-desacetoxycephalosporanic acid derivatives by indium-mediated reduction of 3-iodomethylcephems in aqueous media

被引：22
作者：
Chae, H [1 ]
Cho, S [1 ]
Keum, G [1 ]
Kang, SB [1 ]
Pae, AN [1 ]
Kim, Y [1 ]
机构：
[1] Korea Inst Sci & Technol, Biochem Res Ctr, Seoul 130650, South Korea
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期
关键词：
cephalosporin; halogens and compounds; indium and compounds; dehalogenation; water; reactions in;
D O I：
10.1016/S0040-4039(00)00512-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient reductive conversion of 3-iodomethylcephalosporin and 3-acetoxymethylcephalosporin derivatives mediated by indium into the corresponding 3-methylcephems and 3-methylenecephams in moderate to good yields has been developed in an aqueous system. 3-Methylenecephams are converted into the corresponding 3-methylcephems under previously reported basic conditions quantitatively. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3899 / 3901
页数：3
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