Ultraviolet radiation and immunosuppression

被引：53

作者：

Murphy, G. M. ^{[1
]}

机构：

[1] Beaumont & Mater Misericordiae Hosp, Dept Dermatol, Dublin, Ireland

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2009年 / 161卷

关键词：

apoptosis; carcinogenesis; DNA repair; human papilloma virus; immune surveillance; immuno suppression; ultraviolet radiation; RENAL-TRANSPLANT RECIPIENTS; SKIN IN-VIVO; DELAYED-TYPE HYPERSENSITIVITY; UV-IRRADIATED KERATINOCYTES; PLATELET-ACTIVATING-FACTOR; SQUAMOUS-CELL CARCINOMA; CIS-UROCANIC ACID; HPV E6 PROTEINS; DNA-REPAIR; MALIGNANT-MELANOMA;

D O I：

10.1111/j.1365-2133.2009.09455.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

P>Ultraviolet (UV) radiation is a complete carcinogen. The effects of UV radiation are mediated via direct damage to cellular DNA in the skin and suppression of image surveillance mechanisms. In the context of organ transplantation, addiction of drugs which suppress the immune system add greatly to the carcinogenicity of UV radiation. This review considers the mechanisms of such effects.

引用

页码：90 / 95

页数：6

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