Determination of the lipophilicity of carbonyl derivatives of 2-aminoimidazolines-2 by reversed-phase thin-layer chromatography.: Part 1.: Lipophilicity of 1-(1-arylimidazolin-2-yl)-3-arylureas and 1-aryl-2-imine-3-arylaminocarbonylimidazolidines

The lipophilicity of forty new carbonyl derivatives of 1-aryl-2-aminoimidazolines (twenty 1-(1-arylimidazolin-2-yl)-3-arylureas and twenty 1-aryl-2-imine-3-arylaminocarbonylimidazolidines) has been determined bg reversed-phase thin-layer chromatography (RPTLC) with methanol-acetic acid-water mobile phases. For mobile-phase methanol concentrations within the range 60-90% R-M values of all the compounds were linearly dependent on methanol concentration. Experimental lipophilicity was determined by use of the calibration curves obtained far six standards. Partition coefficients (log P) were calculated for all the compounds by means of the software ChemPlus (HyperChem) and SciLogP (Alchemy 2000) and compared with the experimental Log P values obtained by TLC. It was found that log P values calculated by means of ChemPlus correlated better with values obtained by TLC and thus the methodology of Ghose and co-workers for calculation of partition coefficients is more appropriate for the compounds investigated.