Valproate in children with newly diagnosed idiopathic generalized epilepsy

被引：11

作者：

Holland, K. D. ^{[1
]}

Monahan, S. ^{[1
]}

Morita, D. ^{[1
]}

Vartzelis, G. ^{[1
]}

Glauser, T. A. ^{[1
]}

机构：

[1] Cincinnati Children Hosp, Med Ctr, Div Neurol, Cincinnati, OH 45229 USA

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2010年 / 121卷 / 03期

基金：

美国国家卫生研究院;

关键词：

antiepileptic drugs; child neurology; epilepsy; treatment; neuropharmacology; RANDOMIZED CONTROLLED-TRIAL; ANTIEPILEPTIC DRUG; ABSENCE SEIZURES; LAMOTRIGINE; TOPIRAMATE; OUTCOMES; ACID;

D O I：

10.1111/j.1600-0404.2009.01308.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives - Sparse information on dose-response characteristics for initial antiepileptic drug monotherapy in children with idiopathic generalized epilepsy (IGE) is available. The aim of this study is to characterize the therapeutic dose of valproate in children with newly diagnosed IGE. Materials and methods - Effect of initial valproate monotherapy and doses associated with seizure freedom were examined in consecutive children with IGE identified from a New Onset Seizure Clinic. Results - Of 84 patients identified, 48 (57%) became seizure-free on valproate monotherapy and another 10 patients became seizure-free but discontinued VPA because of adverse effects. The mean dose in seizure-free children was 15.7 mg/kg/day and over 95% of IGE patients will respond below 25 mg/kg/day. Conclusions - Half of children became seizure-free on valproate monotherapy and did so at modest doses.

引用

页码：149 / 153

页数：5

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