Long-term survival case of a non-small cell lung cancer bone metastasis patient treated with bone cement, radiation and gefitinib

被引：2

作者：

Hou, W-T ^{[1
]}

Xie, X-Q ^{[2
]}

Luo, Y. ^{[1
]}

Yi, C. ^{[1
]}

Luo, F. ^{[1
]}

Kang, J-B ^{[3
]}

Wang, F. ^{[1
]}

Lu, Y. ^{[1
]}

Gong, Y-L ^{[1
]}

Wu, D-B ^{[4
]}

Qu, B-L ^{[5
]}

机构：

[1] Sichuan Univ, West China Hosp, West China Med Sch, Dept Med Oncol,Canc Ctr, Chengdu, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Crit Care Med, Chengdu, Sichuan, Peoples R China

[3] Peoples Liberat Army Gen Hosp, Dept Radiotherapy, Med Ctr 6, Beijing, Peoples R China

[4] Angang Grp Gen Hosp, Canc Hosp, Anshan, Liaoning, Peoples R China

[5] Peoples Liberat Army Gen Hosp, Dept Radiotherapy, Med Ctr 1, Beijing, Peoples R China

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2021年 / 25卷 / 06期

关键词：

Bone metastasis; Non-small cell lung cancer; Bone cement; Radiation; Gefitinib; CIRCULATING TUMOR-CELLS; RESISTANCE; MECHANISMS; THERAPY; BENEFIT; IMPACT;

D O I：

10.26355/eurrev_202103_25417

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: We explore the treatment of bone metastases in advanced non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We reported a 76-year-old female patient, who was diagnosed with NSCLC with bone metastasis eight years ago (stage IVA). Due to unbearable diarrhea, she refused chemotherapy, and we adopted local treatment, including local radiotherapy 50 Gy and bone cement to lumbar spinal metastases, 62 Gy local radiotherapy of primary lung tumor, TKI inhibitor gefitinib and zoledronic acid. RESULTS: She survived more than eight years and is still in follow-up. CONCLUSIONS: The median survival time for NSCLC patients with bone metastases is often less than 1 year. We reported the patient with more than eight years of survival, showed that some special cases can adopt the methods of local treatment including bone cement, treatment benefit patients, radiation therapy and targeted therapy in clinic to expand the survival.

引用

页码：2542 / 2547

页数：6

共 27 条

[11] Five-Year Survival in EGFR-Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs [J].

Lin, Jessica J. ;

Cardarella, Stephanie ;

Lydon, Christine A. ;

Dahlberg, Suzanne E. ;

Jackman, David M. ;

Jaenne, Pasi A. ;

Johnson, Bruce E. .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (04) :556-565

[12] Circulating tumor cells in breast cancer:: Correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity [J].

Müller, V ;

Stahmann, N ;

Riethdorf, S ;

Rau, T ;

Zabel, T ;

Goetz, A ;

Janicke, F ;

Pantel, K .

CLINICAL CANCER RESEARCH, 2005, 11 (10) :3678-3685

[13] Combined Cementoplasty and Radiofrequency Ablation in the Treatment of Painful Neoplastic Lesions of Bone [J].

Munk, Peter L. ;

Rashid, Faisal ;

Heran, Manraj K. ;

Papirny, Michael ;

Liu, David M. ;

Malfair, David ;

Badii, Maziar ;

Clarkson, Paul W. .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2009, 20 (07) :903-911

[14] Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer [J].

Nakata, Asuka ;

Gotoh, Noriko .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2012, 16 (08) :771-781

[15] Radiofrequency ablation combined with bone cement injection for the treatment of bone malignancies [J].

Nakatsuka, A ;

Yamakado, K ;

Maeda, M ;

Yasuda, M ;

Akeboshi, M ;

Takaki, H ;

Hamada, A ;

Takeda, K .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2004, 15 (07) :707-712

[16] Retreatment of gefitinib in patients with non-small-cell lung cancer who previously controlled to gefitinib: A single-arm, open-label, phase II study [J].

Oh, In-Jae ;

Ban, Hee-Jung ;

Kim, Kyu-Sik ;

Kim, Young-Chul .

LUNG CANCER, 2012, 77 (01) :121-127

[17] Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial [J].

Patchell, RA ;

Tibbs, PA ;

Regine, WF ;

Payne, R ;

Saris, S ;

Kryscio, RJ ;

Mohiuddin, M ;

Young, B .

LANCET, 2005, 366 (9486) :643-648

[18] Single circulating tumor cell sequencing as an advanced tool in cancer management [J].

Salvianti, Francesca ;

Pazzagli, Mario ;

Pinzani, Pamela .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2016, 16 (01) :51-63

[19] The Emerging Role of Circulating Tumor Cell Detection in Genitourinary Cancer [J].

Small, Alexander C. ;

Gong, Yixuan ;

Oh, William K. ;

Hall, Simon J. ;

van Rijn, Cees J. M. ;

Galsky, Matthew D. .

JOURNAL OF UROLOGY, 2012, 188 (01) :21-26

[20] Predictors of survival in patients with bone metastasis of lung cancer [J].

Sugiura, Hideshi ;

Yamada, Kenji ;

Sugiura, Takahiko ;

Hida, Toyoaki ;

Mitsudomi, Tetsuya .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2008, 466 (03) :729-736

← 1 2 3 →