IL-6 promoter polymorphisms in rheumatoid arthritis

被引：82
|
作者：
Pascual, M
Nieto, A
Matarán, L
Balsa, A
Pascual-Salcedo, D
Martín, J
机构：
[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18001, Spain
[2] Hosp Virgen Nieves, Serv Reumatol, Granada, Spain
[3] Univ Autonoma Madrid, Hosp Univ La Paz, Madrid, Spain
来源：
GENES AND IMMUNITY | 2000年 / 1卷 / 05期
关键词：
IL-6; polymorphism; rheumatoid arthritis;
D O I：
10.1038/sj.gene.6363677
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We investigated the possible association between the IL-6 promoter polymorphisms, at positions -622 and -174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The -622 and -174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset.
引用
收藏
页码：338 / 340
页数：3
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