Preparation and pH responsive behavior of poly(vinyl alcohol)chitosan-poly(acrylic acid) full-IPN hydrogels

被引：24

作者：

Zhang, Ji

Yuan, Kun

Wang, Yun-Pu ^{[1
]}

Zhang, Shen-Tang

Zhang, Ji

机构：

[1] NW Normal Univ, Inst Polymer, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China

[2] NW Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2007年 / 22卷 / 02期

关键词：

poly(vinyl alcohol); chitosan; poly(acrylic acid); pH-sensitive hydrogels; full-interpenetrating polymer network;

D O I：

10.1177/0883911506076046

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A full-interpenetrating polymer network (Full-IPN) hydrogel based on poly(vinyl alcohol)/chitosan/poly(acrylic acid) by the simultaneous-IPN method was synthesized and characterized by FT-IR and scanning electron microscopy. By varying the composition, different gels with different swelling dynamics, pH behavior and shrinking behavior of the gels were obtained. All the hydrogels swelled and reached equilibrium within five hours, indicating that the hydrogels have fast swelling properties and a relatively high swelling ratio (SR). Increasing the hydrophilic PAA in the full-IPN hydrogels increased the SR. The introduction of PVA and CTS to the full-IPN enhanced the hydrogel's biocompatibility. The poly(vinyl alcohol)/chitosan/poly(acrylic acid) full-IPN hydrogels exhibited a swelling change in response to pH of the swelling medium, and could be useful a potential modulation systems in biomedical fields.

引用

页码：207 / 218

页数：12

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