Application of microfluidic chip technology in pharmaceutical analysis: A review

被引：271
作者：
Cui, Ping [1 ,2 ]
Wang, Sicen [1 ,2 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Pharm, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
[2] Shaanxi Engn Res Ctr Cardiovasc Drugs Screening &, Xian 710061, Shaanxi, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL ANALYSIS | 2019年 / 9卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Microfluidic chip; Pharmaceutical analysis; Application research; ON-A-CHIP; ENHANCED RAMAN-SPECTROSCOPY; HIGH-THROUGHPUT; LIQUID-CHROMATOGRAPHY; CELL-CULTURE; MASS-SPECTROMETRY; DRUG-RESISTANCE; RAPID DETECTION; HUMAN URINE; ASSAY;
D O I：
10.1016/j.jpha.2018.12.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening, detection and mechanistic study of drugs. This review highlights the latest (2010-2018) microfluidic technology for drug analysis and discusses the potential future development in this field. (C) 2018 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
引用
收藏
页码：238 / 247
页数：10
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