Evaluation of the glycemic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: A pilot study

被引：22

作者：

Dehpouri, Tannaz ^{[1
]}

Rokni, Ghasem Rahmatpour ^{[2
]}

Narenjbon, Nematollah Ahangar ^{[3
]}

Goldust, Mohamad ^{[2
]}

Yamauchi, Paul S. ^{[4
,5
,6
]}

Wollina, Uwe ^{[7
]}

Lotti, Torello ^{[8
]}

Kircik, Leon ^{[9
]}

Di Lernia, Vito Giuseppe ^{[10
]}

Sonthalia, Sidharth ^{[11
,12
]}

Vojvodic, Aleksandra ^{[13
]}

Szepietowski, Jacek ^{[14
]}

Bahadoran, Philippe ^{[15
]}

Errichetti, Enzo ^{[16
]}

Cantisani, Carmen ^{[17
]}

Atzori, Laura ^{[18
]}

Rezaee, Elham ^{[19
]}

Kutlubay, Zekayi ^{[20
]}

Engin, Burhan ^{[20
]}

Nistico, Steven ^{[21
]}

Damiani, Giovanni ^{[22
,23
]}

Conic, Rosalynn R. Z. ^{[24
]}

Goren, Andy ^{[8
]}

Cabrijan, Leo ^{[25
]}

Tchernev, Georgi ^{[26
]}

机构：

[1] Mazandaran Univ Med Sci, Ramsar Int Branch, Student Res Comm, Ramsar, Iran

[2] Mazandaran Univ Med Sci, Dept Dermatol, Sari, Iran

[3] Mazandaran Univ Med Sci, Fac Pharm, Dept Pharmacol, Sari, Iran

[4] Dermatol Inst, Santa Monica, CA USA

[5] Skin Care Ctr, Santa Monica, CA USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA

[7] Tech Univ Dresden, Dept Dermatol & Allergol, Stadt Klinikum Dresden, Acad Teaching Hosp, Dresden, Germany

[8] Guglielmo Marconi Univ, Dept Dermatol, Rome, Italy

[9] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[10] Santa Maria Nuova IRCCS Hosp, Dermatol Unit, Reggio Emilia, Italy

[11] Skinnocence Skin Clin & Res Ctr, Gurugram, Haryana, India

[12] Dermasource India, Gurugram, Haryana, India

[13] Mil Med Acad, Dept Dermatol & Venereol, Belgrade, Serbia

[14] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland

[15] Univ Hosp Nice, Dept Dermatol, Nice, France

[16] Univ Udine, Inst Dermatol, Dept Expt & Clin Med, Udine, Italy

[17] Sapienza Univ Rome, Umberto I Hosp, Dept Dermatol, Rome, Italy

[18] Univ Cagliari, Dept Med Sci & Publ Hlth, Dermatol Clin, Cagliari, Italy

[19] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran

[20] Istanbul Univ, Cerrahpasa Fac Med, Dept Dermatol, Istanbul, Turkey

[21] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[22] Univ Milan, IRCCS Ca Granda Fdn, Dept Med & Surg Pathophysiol & Transplantat, Dermatol Unit,Osped Maggiore Policlin, Milan, Italy

[23] Ctr Studi GISED, YDIN, Bergamo, Italy

[24] Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA

[25] Rijeka Clin Hosp Ctr, Dept Dermatovenereol, Rijeka, Croatia

[26] Minist Interior MVR, Med Inst, Dept Dermatol Venereol & Dermatol Surg, Sofia, Bulgaria

来源：

DERMATOLOGY REPORTS | 2019年 / 11卷 / 01期

关键词：

Psoriatic arthritis; Metabolic syndrome; HbA1c; Methotrexate; RHEUMATOID-ARTHRITIS; ALPHA BLOCKADE; HEMOGLOBIN; RISK; ASSOCIATION; PREVALENCE; MORTALITY; DIAGNOSIS; MODERATE; THERAPY;

D O I：

10.4081/dr.2019.7965

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Methotrexate (MTX) is a systemic immunosuppressant drug used for the treatment of psoriasis and psoriatic arthritis. Previous studies demonstrated a potential association between psoriasis and diabetes mellitus, obesity, atherosclerosis, hypertension, eventuating into metabolic syndrome. This study aimed at exploring the glycemic effects of MTX in psoriatic arthritis (PsA) patients. In this prospective cross-sectional study, 27 patients with PsA were evaluated. The status of PsA and presence of accompanying metabolic syndrome was determined by standard criteria and indices. Blood indicators including HbA1c, erythrocyte sedimentation rate, fasting blood sugar, total cholesterol, high-density lipoprotein, triglycerides, and C-reactive protein were examined before and 12 weeks after MTX therapy. There were no significant changes between HbA1c levels before and after MTX therapy in both genders (men: P=0.131, women: P=0.803). In addition,HbA1c levels in PsA patients with metabolic syndrome were not different before and after treatment (P=0.250). Finally, HbA1c levels did not change in PsA patients without metabolic syndrome before and after therapy (P=0.506). MTX in PsA patients does not appear to have hyperglycaemic effects in the short-term and can be safely used in patients with metabolic syndrome and diabetes.

引用

页码：22 / 26

页数：5

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