Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes

被引：19

作者：

Ataseyer-Arslan, Belkis ^{[1
]}

Yilancioglu, Kaan ^{[2
]}

Kalkan, Zeynep ^{[2
,3
]}

Timucin, Ahmet Can ^{[4
]}

Gur, Hazal ^{[2
]}

Isik, Fatma Busra ^{[1
]}

Deniz, Emre ^{[4
,5
]}

Erman, Batu ^{[4
,5
]}

Cetiner, Selim ^{[4
]}

机构：

[1] Uskudar Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkey

[2] Uskudar Univ, Fac Engn & Nat Sci, Dept Bioengn, Istanbul, Turkey

[3] Uskudar Univ, Hlth Sci Inst, Neurosci Program, Istanbul, Turkey

[4] Sabanci Univ, Fac Engn & Nat Sci, Mol Biol Genet & Bioengn Program, Istanbul, Turkey

[5] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, Istanbul, Turkey

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 83卷

关键词：

Algae; Essential oils; Leukemia; GC-MS; MOLECULAR-DYNAMICS; INHIBITORS; APOPTOSIS; POTENT; OPTIMIZATION; DESIGN; CELLS;

D O I：

10.1016/j.ejps.2015.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microalgae are very rich in bioactive compounds, minerals, polysaccharides, poly-unsaturated fatty acids and vitamins, and these rich constituents make microalgae an important resource for the discovery of new bioactive compounds with applications in biotechnology. In this study, we studied the antileukemic activity of several chosen microalgae species at the molecular level and assessed their potential for drug development. Here we identified Stichococcus bacillaris, Phaeodactylum tricornutum, Microcystis aeruginosa and Nannochloropsis oculata microalgae extracts with possible antileukemic agent potentials. Specifically we studied the effects of these extracts on intracellular signal nodes and apoptotic pathways. We characterized the composition of essential oils of these fifteen different algae extracts using gas chromatography-mass spectrometry (GC-MS). Finally, to identify potential molecular targets causing the phenotypic changes in leukemic cell lines, we docked a selected group of these essential oils to several key intracellular proteins. According to results of rank score algorithm, five of these essential oils analyzed might be considered as in silico plausible candidates to be used as antileukemic agents. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：120 / 131

页数：12

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