Emerging pollutants and plants - Metabolic activation of diclofenac by peroxidases

被引：55

作者：

Huber, Christian ^{[1
]}

Preis, Martina ^{[2
]}

Harvey, Patricia J. ^{[2
]}

Grosse, Sylvia ^{[3
]}

Letzel, Thomas ^{[3
]}

Schroeder, Peter ^{[1
]}

机构：

[1] Helmholtz Zentrum Munchen Deutsch Forschungszentr, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany

[2] Univ Greenwich, Sch Sci, Cent Ave, Chatham ME4 4TB, Kent, England

[3] Tech Univ Munich, Lehrstuhl Siedlungswasserwirtschaft, D-85748 Garching, Germany

来源：

CHEMOSPHERE | 2016年 / 146卷

关键词：

Diclofenac; Iminoquinone; Peroxidase; Stopped flow spectroscopy; LC-MS; TYPHA-LATIFOLIA; DRINKING-WATER; OXIDATION; FATE; MYELOPEROXIDASE; IDENTIFICATION; GEMFIBROZIL; TOXICITY; REMOVAL; CADMIUM;

D O I：

10.1016/j.chemosphere.2015.12.059

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Human pharmaceuticals and their residues are constantly detected in our waterbodies, due to poor elimination rates, even in the most advanced waste water treatment plants. Their impact on the environment and human health still remains unclear. When phytoremediation is applied to aid water treatment, plants may transform and degrade xenobiotic contaminants through phase I and phase II metabolism to more water soluble and less toxic intermediates. In this context, peroxidases play a major role in activating compounds during phase I via oxidation. In the present work, the ability of a plant peroxidase to oxidize the human painkiller diclofenac was confirmed using stopped flow spectroscopy in combination with LC-MS analysis. Analysis of an orange colored product revealed the structure of the highly reactive Diclofenac-2,5-Iminoquinone, which may be the precursor of several biological conjugates and breakdown products in planta. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：435 / 441

页数：7

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