Neuromyelitis optica: Effect of gender

被引:74
作者
Wingerchuk, Dean M. [1 ]
机构
[1] Mayo Clin, Coll Med, Scottsdale, AZ 85259 USA
关键词
Neuromyelitis optica; Gender; Multiple sclerosis; MITOCHONDRIAL-DNA MUTATIONS; SPINAL-CORD LESIONS; MULTIPLE-SCLEROSIS; DEVICS-SYNDROME; CLINICAL-COURSE; NMO-IGG; ANTI-AQUAPORIN-4; ANTIBODY; AQUAPORIN-4; AUTOIMMUNITY; RETROSPECTIVE ANALYSIS; HLA TYPES;
D O I
10.1016/j.jns.2009.08.045
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neuromyelitis optica is a distinct CNS demyelinating disease associated with the autoantibody NMO-IgG, which targets the water channel aquaporin-4. Neuromyelitis optica may be distinguished from typical multiple sclerosis on the basis of key clinical and neuroimaging characteristics in addition to detection of NMO-IgG. The disease has an even stronger female predilection than does multiple sclerosis, with a reasonably consistent female to male gender ratio of >3:1 reported from samples of diverse racial and regional populations worldwide. The gender distribution appears to be similar in both childhood-onset and adult-onset cases. Female gender is associated with a relapsing course and familial disease, but the influence of gender on disease severity and treatment response are not clear. Population-based epidemiological and genetic studies, with case ascertainment aided by the high specificity of NMO-IgG and consistent disease definitions, are needed to better define and understand gender effects in neuromyelitis optica. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:18 / 23
页数:6
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