Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

被引：56
作者：
Butin, Alexander V.
Smirnov, Sergey K.
Stroganova, Tatyana A.
Bender, Wolfgang
Krapivin, Gennady D.
机构：
[1] Kuban State Univ Technol, Res Inst Heterocycl Cpds Chem, Krasnodar 350072, Russia
[2] Bayer HealthCare, D-51368 Leverkusen, Germany
来源：
TETRAHEDRON | 2007年 / 63卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
furan; recyclization; indoles;
D O I：
10.1016/j.tet.2006.10.056
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：474 / 491
页数：18
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