pH-sensitive carboxymethyl chitosan hydrogels via acid-labile ortho ester linkage as an implantable drug delivery system

被引：42

作者：

Gao, Jialu ^{[1
]}

Xu, Yong ^{[1
]}

Zheng, Yan ^{[1
]}

Wang, Xin ^{[1
]}

Li, Shuting ^{[1
]}

Yan, Guoqing ^{[1
]}

Wang, Jun ^{[1
]}

Tang, Rupei ^{[1
]}

机构：

[1] Anhui Univ, Sch Life Sci, Anhui Key Lab Modern Biomfg, Engn Res Ctr Biomed Mat, 111 Jiu long Rd, Hefei 230601, Anhui, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2019年 / 225卷

基金：

中国国家自然科学基金;

关键词：

Chitosan; Orthoester; Hydrogels; Drug delivery; Chemotherapy; GELATIN NANOPARTICLES; POLYMER IMPLANTS; DIGLYCIDYL ETHER; GLYCOL CHITOSAN; IN-VITRO; RELEASE; CISPLATIN;

D O I：

10.1016/j.carbpol.2019.115237

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of pH-sensitive carboxymethyl chitosan (CMCS) hydrogels were prepared via ortho ester linkage. DOX-loaded gelatin nanoparticles with an average diameter of around 50 nm were incorporated into hydrogels to obtain hybrid hydrogels (DOX-NPs-Gel), which could be locally implanted into tumor site in any shape. The physicochemical and mechanical properties of these hydrogels could be easily controlled by adjusting the proportion of crosslinking agent. DOX-NPs-Gel showed the pH-dependent degradation and drug release, and only 29.9% of DOX was released within 144 hat pH 7.4, while the cumulative release reached 49.3% and 65% at pH 6.5 and 5.0, respectively. In vivo study demonstrated that the implanted DOX-NPs-Gel efficiently improved DOX accumulation in tumor site through continuously degradation in mildly acidic environment of tumor tissues, and the tumor volume at the end of experiment was only 81.53 mm(3), while tumor size reached to 229.22 mm(3) and 174.15 mm(3) after intravenous treatment with free DOX and DOX-NPs, respectively.

引用

页数：9

共 43 条

[21] Antitumor effects of various low-molecular-weight chitosans are due to increased natural killer activity of intestinal intraepithelial lymphocytes in sarcoma 180-bearing mice [J].