The Era of Genomic Epidemiology

被引：9
作者：
Traynor, Bryan J. [1 ,2 ]
机构：
[1] NIA, Neurogenet Lab, NIH, Neuromuscular Dis Res Grp, Bethesda, MD 20892 USA
[2] NINDS, Neurogenet Branch, Bethesda, MD 20892 USA
来源：
NEUROEPIDEMIOLOGY | 2009年 / 33卷 / 03期
关键词：
Genetics; Genomics; Epidemiology; AMYOTROPHIC-LATERAL-SCLEROSIS; WIDE ASSOCIATION; PARKINSONS-DISEASE; PROSTATE-CANCER; CORONAVIRUS; MUTATIONS; SEQUENCE; AGE;
D O I：
10.1159/000235639
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The recent revolution in genomics is already having a profound impact on the practice of epidemiology. The purpose of this commentary is to demonstrate how genomics and epidemiology will continue to rely heavily on each other, now and in the future, by illustrating a number of interaction points between these 2 disciplines: (1) the use of genomics to estimate disease heritability; (2) the impact of genomics on analytical study design; (3) how genome-wide data can be employed to effectively overcome residual population stratification arising from selection bias; (4) the importance of genomics as a tool in epidemiological investigation; (5) the importance of epidemiology in the collection of adequately phenotyped samples for genomics studies, and (6) for unraveling the clinical and therapeutic relevance of genetic variants once they are discovered. Copyright (c) 2009 S. Karger AG, Basel
引用
收藏
页码：276 / 279
页数：4
相关论文
共 20 条
  • [1] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Barrett, Jeffrey C.
    Hansoul, Sarah
    Nicolae, Dan L.
    Cho, Judy H.
    Duerr, Richard H.
    Rioux, John D.
    Brant, Steven R.
    Silverberg, Mark S.
    Taylor, Kent D.
    Barmada, M. Michael
    Bitton, Alain
    Dassopoulos, Themistocles
    Datta, Lisa Wu
    Green, Todd
    Griffiths, Anne M.
    Kistner, Emily O.
    Murtha, Michael T.
    Regueiro, Miguel D.
    Rotter, Jerome I.
    Schumm, L. Philip
    Steinhart, A. Hillary
    Targan, Stephan R.
    Xavier, Ramnik J.
    Libioulle, Cecile
    Sandor, Cynthia
    Lathrop, Mark
    Belaiche, Jacques
    Dewit, Olivier
    Gut, Ivo
    Heath, Simon
    Laukens, Debby
    Mni, Myriam
    Rutgeerts, Paul
    Van Gossum, Andre
    Zelenika, Diana
    Franchimont, Denis
    Hugot, Jean-Pierre
    de Vos, Martine
    Vermeire, Severine
    Louis, Edouard
    Cardon, Lon R.
    Anderson, Carl A.
    Drummond, Hazel
    Nimmo, Elaine
    Ahmad, Tariq
    Prescott, Natalie J.
    Onnie, Clive M.
    Fisher, Sheila A.
    Marchini, Jonathan
    Ghori, Jilur
    [J]. NATURE GENETICS, 2008, 40 (08) : 955 - 962
  • [2] A genetic link between type 2 diabetes and prostate cancer - Commentary
    Frayling, T. M.
    Colhoun, H.
    Florez, J. C.
    [J]. DIABETOLOGIA, 2008, 51 (10) : 1757 - 1760
  • [3] Common LRRK2 mutation in idiopathic Parkinson's disease
    Gilks, WP
    Abou-Sleiman, PM
    Gandhi, S
    Jain, S
    Singleton, A
    Lees, AJ
    Shaw, K
    Bhatia, KP
    Bonifati, V
    Quinn, NP
    Lynch, J
    Healy, DG
    Holton, JL
    Revesz, T
    Wood, NW
    [J]. LANCET, 2005, 365 (9457) : 415 - 416
  • [4] Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Gudmundsson, Julius
    Sulem, Patrick
    Steinthorsdottir, Valgerdur
    Bergthorsson, Jon T.
    Thorleifsson, Gudmar
    Manolescu, Andrei
    Rafnar, Thorunn
    Gudbjartsson, Daniel
    Agnarsson, Bjarni A.
    Baker, Adam
    Sigurdsson, Asgeir
    Benediktsdottir, Kristrun R.
    Jakobsdottir, Margret
    Blondal, Thorarinn
    Stacey, Simon N.
    Helgason, Agnar
    Gunnarsdottir, Steinunn
    Olafsdottir, Adalheidur
    Kristinsson, Kari T.
    Birgisdottir, Birgitta
    Ghosh, Shyamali
    Thorlacius, Steinunn
    Magnusdottir, Dana
    Stefansdottir, Gerdur
    Kristjansson, Kristleifur
    Bagger, Yu
    Wilensky, Robert L.
    Reilly, Muredach P.
    Morris, Andrew D.
    Kimber, Charlotte H.
    Adeyemo, Adebowale
    Chen, Yuanxiu
    Zhou, Jie
    So, Wing-Yee
    Tong, Peter C. Y.
    Ng, Maggie C. Y.
    Hansen, Torben
    Andersen, Gitte
    Borch-Johnsen, Knut
    Jorgensen, Torben
    Tres, Alejandro
    Fuertes, Fernando
    Ruiz-Echarri, Manuel
    Asin, Laura
    Saez, Berta
    van Boven, Erica
    Klaver, Siem
    Swinkels, Dorine W.
    Aben, Katja K.
    Graif, Theresa
    [J]. NATURE GENETICS, 2007, 39 (08) : 977 - 983
  • [5] Hindorff L., CATALOG PUBLISHED GE
  • [6] The emergence of epidemiology in the genomics age
    Khoury, MJ
    Millikan, R
    Little, J
    Gwinn, M
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (05) : 936 - 944
  • [7] Complement factor H polymorphism in age-related macular degeneration
    Klein, RJ
    Zeiss, C
    Chew, EY
    Tsai, JY
    Sackler, RS
    Haynes, C
    Henning, AK
    SanGiovanni, JP
    Mane, SM
    Mayne, ST
    Bracken, MB
    Ferris, FL
    Ott, J
    Barnstable, C
    Hoh, J
    [J]. SCIENCE, 2005, 308 (5720) : 385 - 389
  • [8] Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway
    Lesnick, Timothy G.
    Sorenson, Eric J.
    Ahlskog, J. Eric
    Henley, John R.
    Shehadeh, Lina
    Papapetropoulos, Spiridon
    Maraganore, Demetrius M.
    [J]. PLOS ONE, 2008, 3 (01):
  • [9] MACREADY N, 2008, NEUROLOGY TODAY, V8, P36
  • [10] The genome sequence of the SARS-associated coronavirus
    Marra, MA
    Jones, SJM
    Astell, CR
    Holt, RA
    Brooks-Wilson, A
    Butterfield, YSN
    Khattra, J
    Asano, JK
    Barber, SA
    Chan, SY
    Cloutier, A
    Coughlin, SM
    Freeman, D
    Girn, N
    Griffith, OL
    Leach, SR
    Mayo, M
    McDonald, H
    Montgomery, SB
    Pandoh, PK
    Petrescu, AS
    Robertson, AG
    Schein, JE
    Siddiqui, A
    Smailus, DE
    Stott, JE
    Yang, GS
    Plummer, F
    Andonov, A
    Artsob, H
    Bastien, N
    Bernard, K
    Booth, TF
    Bowness, D
    Czub, M
    Drebot, M
    Fernando, L
    Flick, R
    Garbutt, M
    Gray, M
    Grolla, A
    Jones, S
    Feldmann, H
    Meyers, A
    Kabani, A
    Li, Y
    Normand, S
    Stroher, U
    Tipples, GA
    Tyler, S
    [J]. SCIENCE, 2003, 300 (5624) : 1399 - 1404
12