Recent advances in polymeric micelles for anti-cancer drug delivery

被引：378

作者：

Biswas, Swati ^{[1
]}

Kumari, Preeti ^{[1
]}

Lakhani, Prit Manish ^{[1
]}

Ghosh, Balaram ^{[1
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Hyderabad 500078, Telangana, India

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 83卷

关键词：

Polymeric micelles; Block polymer; EPR effect; Anticancer; Targeted delivery; Cancer therapy; BLOCK-COPOLYMER MICELLES; PEG-PLGA NANOPARTICLES; THERMOSENSITIVE DIBLOCK COPOLYMER; IRON-OXIDE NANOPARTICLES; TUMOR-TARGETED DELIVERY; IN-VIVO EVALUATION; POLY(ETHYLENE GLYCOL); PHOTODYNAMIC THERAPY; MIXED MICELLES; CO-DELIVERY;

D O I：

10.1016/j.ejps.2015.12.031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Block co-polymeric micelles receive increased attention due to their ability to load therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the loaded drug and reduce off-target cytotoxicity. While polymeric micelles can be developed with improved drug loading capabilities by modulating hydrophobicity and hydrophilicity of the micelle forming block co-polymers, they can also be successfully cancer targeted by surface modifying with tumor-homing ligands. However, maintenance of the integrity of the self-assembled system in the circulation and disassembly for drug release at the site of drug action remain a challenge. Therefore, stimuli-responsive polymeric micelles for on demand drug delivery with minimal off-target effect has been developed and extensively investigated to assess their sensitivity. This review focuses on discussing various polymeric micelles currently utilized for the delivery of chemotherapeutic drugs. Designs of various stimuli-sensitive micelles that are able to control drug release in response to specific stimuli, either endogenous or exogenous have been delineated. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：184 / 202

页数：19

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