Successful treatment of minimal residual disease-positive Philadelphia chromosome-positive acute lymphoblastic leukemia with imatinib followed by reduced-intensity unrelated cord blood transplantation after allogeneic peripheral blood stem cell transplantation

被引：2

作者：

Takami, Akiyoshi

Shimadoi, Shigeru

Sugimori, Chiharu

Takemoto, Kenichi

Shibayama, Masami

Yoshida, Tomotaka

Murayama, Tohru

Nagai, Kenichi

Miyamura, Koichi

Asakura, Hidesaku

Nakao, Shinji

机构：

[1] Kanazawa Univ, Dept Cellular Transplantat Biol, Grad Sch Med, Kanazawa, Ishikawa 9208641, Japan

[2] Kanazawa Univ, Dept Lab Med, Grad Sch Med, Kanazawa, Ishikawa 9208641, Japan

[3] Kobe City Gen Hosp, Dept Hematol & Clin Immunol, Kobe, Hyogo, Japan

[4] Hyogo Med Ctr Adults, Dept Hematol, Akashi, Hyogo, Japan

[5] Japanese Red Cross Nagoya First Hosp, Dept Hematol, Nagoya, Aichi, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2006年 / 84卷 / 02期

关键词：

Philadelphia chromosome-positive acute lymphoblastic leukemia; unrelated cord blood transplantation; imatinib; minimal residual disease;

D O I：

10.1532/IJH97.06066

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a 35-year-old woman with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who received allogeneic sibling donor peripheral blood stem cell transplantation (PBSCT) and entered a second complete remission. Upon detection of BCR-ABL transcripts after PBSCT, the patient received imatinib, leading to molecular remission. Following the failure of donor leukocyte infusions, she underwent reduced-intensity unrelated cord blood transplantation (RI-UCBT), and has continued durable molecular remission for more than 30 months without substantial graft-versus-host disease. Because of a lack of adverse effects of imatinib on transplantation outcome, a treatment strategy consisting of molecular monitoring-guided initiation of imatinib followed by RI-UCBT may be promising in the management of Ph+ ALL after allogeneic SCT.

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页码：170 / 173

页数：4

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