The exocyst complex in polarized exocytosis

被引：332
作者：
He, Bing [1 ]
Guo, Wei [1 ]
机构：
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 04期
基金：
美国国家卫生研究院;
关键词：
PLASMA-MEMBRANE; SACCHAROMYCES-CEREVISIAE; CRYSTAL-STRUCTURE; SEC6/8; COMPLEX; YEAST; INTERACTS; GTPASE; SNARE; EFFECTOR; SUBUNIT;
D O I：
10.1016/j.ceb.2009.04.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The exocyst is an octameric protein complex, which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane before exocytic fusion. The exocyst assembles by side-by-side packing of rod-shaped subunits composed of helical bundles. The targeting of secretory vesicles to the plasma membrane involves direct interactions of the exocyst with PI(4,5)P-2. In addition, a number of small GTP-binding proteins interact with components of the exocyst and regulate the assembly, localization, and function of this complex. Here we review the recent advances in the field, focusing on the function of the exocyst in polarized exocytosis.
引用
收藏
页码：537 / 542
页数：6
相关论文
共 52 条
  • [1] Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud
    Adamo, JE
    Moskow, JJ
    Gladfelter, AS
    Viterbo, D
    Lew, DJ
    Brennwald, PJ
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 155 (04) : 581 - 592
  • [2] The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity
    Adamo, JE
    Rossi, G
    Brennwald, P
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (12) : 4121 - 4133
  • [3] Snapin interacts with the exo70 subunit of the exocyst and modulates GLUT4 trafficking
    Bao, Yiqun
    Lopez, Jamie A.
    James, David E.
    Hunziker, Walter
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (01) : 324 - 331
  • [4] Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p
    Boyd, C
    Hughes, T
    Pypaert, M
    Novick, P
    [J]. JOURNAL OF CELL BIOLOGY, 2004, 167 (05) : 889 - 901
  • [5] Structural analysis of conserved oligomeric golgi complex subunit 2
    Cavanaugh, Lorraine F.
    Chen, Xiaocheng
    Richardson, Brian C.
    Ungar, Daniel
    Pelczer, Istvan
    Rizo, Josep
    Hughson, Frederick M.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (32) : 23418 - 23426
  • [6] The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif
    Dong, G
    Hutagalung, AH
    Fu, CM
    Novick, P
    Reinisch, KM
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (12) : 1094 - 1100
  • [7] Sec3p is a spatial landmark for polarized secretion in budding yeast
    Finger, FP
    Hughes, TE
    Novick, P
    [J]. CELL, 1998, 92 (04) : 559 - 571
  • [8] The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains
    Fölsch, H
    Pypaert, M
    Maday, S
    Pelletier, L
    Mellman, I
    [J]. JOURNAL OF CELL BIOLOGY, 2003, 163 (02) : 351 - 362
  • [9] Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
    Grindstaff, KK
    Yeaman, C
    Anandasabapathy, N
    Hsu, SC
    Rodriguez-Boulan, E
    Scheller, RH
    Nelson, WJ
    [J]. CELL, 1998, 93 (05) : 731 - 740
  • [10] The yeast IgI family member Sro7p is an effector of the secretory Rab GTPase Sec4p
    Grosshans, BL
    Andreeva, A
    Gangar, A
    Niessen, S
    Yates, JR
    Brennwald, P
    Novick, P
    [J]. JOURNAL OF CELL BIOLOGY, 2006, 172 (01) : 55 - 66
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