Location of a major susceptibility locus for familiar schizophrenia on chromosome 1q21-q22

被引：391

作者：

Brzustowicz, LM ^{[1
]}

Hodgkinson, KA

Chow, EWC

Honer, WG

Bassett, AS

机构：

[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA

[3] Univ Toronto, Dept Psychiat, Toronto, ON M6J 1H4, Canada

[4] Univ Toronto, Ctr Addict & Mental Hlth, Schizophrenia Res Program, Genet Sect, Toronto, ON M6J 1H4, Canada

[5] Univ British Columbia, Dept Psychiat, Vancouver, BC V6H 3Z6, Canada

来源：

SCIENCE | 2000年 / 288卷 / 5466期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1126/science.288.5466.678

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings, A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity Logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

引用

页码：678 / 682

页数：5

共 42 条

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