Location of a major susceptibility locus for familiar schizophrenia on chromosome 1q21-q22

被引：392

作者：

Brzustowicz, LM ^{[1
]}

Hodgkinson, KA

Chow, EWC

Honer, WG

Bassett, AS

机构：

[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA

[3] Univ Toronto, Dept Psychiat, Toronto, ON M6J 1H4, Canada

[4] Univ Toronto, Ctr Addict & Mental Hlth, Schizophrenia Res Program, Genet Sect, Toronto, ON M6J 1H4, Canada

[5] Univ British Columbia, Dept Psychiat, Vancouver, BC V6H 3Z6, Canada

来源：

SCIENCE | 2000年 / 288卷 / 5466期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1126/science.288.5466.678

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings, A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity Logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

引用

页码：678 / 682

页数：5

共 42 条

[1] Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases [J].

Abreu, PC ;

Greenberg, DA ;

Hodge, SE .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (03) :847-857

[2] POSITIVE AND NEGATIVE SYMPTOMS IN FAMILIES WITH SCHIZOPHRENIA [J].

BASSETT, AS ;

COLLINS, EJ ;

NUTTALL, SE ;

HONER, WG .

SCHIZOPHRENIA RESEARCH, 1993, 11 (01) :9-19

[3]

BASSETT AS, 1994, AM J HUM GENET, V54, P864

[4] Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21 [J].

Blouin, JL ;

Dombroski, BA ;

Nath, SK ;

Lasseter, VK ;

Wolyniec, PS ;

Nestadt, G ;

Thornquist, M ;

Ullrich, G ;

McGrath, J ;

Kasch, L ;

Lamacz, M ;

Thomas, MG ;

Gehrig, C ;

Radhakrishna, U ;

Snyder, SE ;

Balk, KG ;

Neufeld, K ;

Swartz, KL ;

DeMarchi, N ;

Papadimitriou, GN ;

Dikeos, DG ;

Stefanis, CN ;

Chakravarti, A ;

Childs, B ;

Housman, DE ;

Kazazian, HH ;

Antonarakis, SE ;

Pulver, AE .

NATURE GENETICS, 1998, 20 (01) :70-73

[5]

Brzustowicz LM, 1999, AM J HUM GENET, V65, P1096, DOI 10.1086/302579

[6] Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p [J].

Brzustowicz, LM ;

Honer, WG ;

Chow, EWC ;

Hogan, J ;

Hodgkinson, K ;

Bassett, AS .

AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (06) :1388-1396

[7]

Cloninger CR, 1998, AM J MED GENET, V81, P275, DOI 10.1002/(SICI)1096-8628(19980710)81:4<275::AID-AJMG1>3.3.CO

[8]

2-U

[9] GENOMIC SCAN FOR GENES PREDISPOSING TO SCHIZOPHRENIA [J].

COON, H ;

JENSEN, S ;

HOLIK, J ;

HOFF, M ;

MYLESWORSLEY, M ;

REIMHERR, F ;

WENDER, P ;

WALDO, M ;

FREEDMAN, R ;

LEPPERT, M ;

BYERLEY, W .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1994, 54 (01) :59-71

[10]

COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252

← 1 2 3 4 5 →