Insulating behavior of λ-DNA on the micron scale -: art. no. 198102

被引：196

作者：

Zhang, Y ^{[1
]}

Austin, RH

Kraeft, J

Cox, EC

Ong, NP

机构：

[1] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

PHYSICAL REVIEW LETTERS | 2002年 / 89卷 / 19期

关键词：

D O I：

10.1103/PhysRevLett.89.198102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We have investigated the electrical conductivity of lambda-DNA using DNA covalently bonded to Au electrodes. Thiol-modified dTTP was incorporated into the "sticky" ends of bacteriophage lambda-DNA using DNA polymerase. Two-probe measurements on such molecules provide a hard lower bound for the resistivity rho > 10(6)Omega cm at bias potentials up to 20 V, in conflict with recent claims of moderate to high conductivity. By direct imaging, we show that the molecules are present after the measurements. We stress the importance of eliminating salt residues in these measurements.

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页数：4

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