Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin's lymphoma: a reflection of disease infiltration or just inflammation?

被引:96
作者
Salaun, Pierre Y. [2 ,3 ]
Gastinne, Thomas [4 ]
Bodet-Milin, Caroline [1 ]
Campion, Loic [5 ,7 ]
Cambefort, Pierre [2 ]
Moreau, Anne [6 ]
Le Gouill, Steven [4 ,7 ]
Berthou, Christian [8 ]
Moreau, Philippe [4 ,7 ]
Kraeber-Bodere, Francoise [1 ,3 ,7 ]
机构
[1] Univ Hosp Nantes, Dept Nucl Med, Nantes, France
[2] Univ Hosp Brest, Dept Nucl Med, Brest, France
[3] Rene Gauducheau Canc Ctr, Dept Nucl Med, Nantes, France
[4] Univ Hosp Nantes, Dept Haematol, Nantes, France
[5] Rene Gauducheau Canc Ctr, Biostat Unit, Nantes, France
[6] Univ Hosp Nantes, Dept Histopathol, Nantes, France
[7] INSERM, CRCNA, UMR 892, Nantes, France
[8] Univ Hosp Brest, Dept Haematol, Brest, France
关键词
FDG PET; Hodgkin's lymphoma; Bone marrow involvement; Inflammation; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; COMPUTED-TOMOGRAPHY; AGGRESSIVE LYMPHOMA; MALIGNANT-LYMPHOMA; PROGNOSTIC SCORE; INVOLVEMENT; LAPAROTOMY; BIOPSY; CHEMOTHERAPY;
D O I
10.1007/s00259-009-1183-0
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
F-18-FDG PET has been successfully evaluated in the management of Hodgkin's lymphoma (HL) and the most recent international guidelines recommended F-18-FDG PET for initial staging and final therapeutic assessment. However, F-18-FDG PET diffuse bone marrow uptake (BMU) and splenic uptake (SU) are frequently observed at the initial imaging and remain difficult to analyse. The aim of this retrospective study was to evaluate the significance of F-18-FDG diffuse BMU and SU in initial staging of HL. A total of 106 patients (median age: 31 years, range: 9-81, 51 female, 55 male) underwent F-18-FDG PET/CT for initial staging of HL. BMU level was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake) and semi-quantitatively using the maximum standardized uptake value (SUVmax) measured in the sacral area. SU was assessed visually according to liver uptake (1 = below liver uptake, 2 = corresponding to liver uptake, 3 = above liver uptake). These data were compared with the patient's characteristics including sex, age, Ann Arbor staging, bulky disease (tumour burden > 10 cm), presence of B symptoms, bone foci on PET (n = 106), bone marrow involvement (BMI) on biopsy (n = 75), leukocyte count (n = 74), lactic dehydrogenase (LDH) (n = 87), C-reactive protein (CRP) (n = 83) and fibrinogen (n = 60). Univariate and multivariate analyses were performed. Multivariate analysis found an independent correlation between BMU visual grading and CRP level (p = 0.007). For semi-quantitative BMU evaluation, multivariate analysis found an independent correlation between sacral SUVs and CRP level (p = 0.032) and Ann Arbor stage (p = 0.005). No BMI was found in patients who presented with SUVmax below 3.4. For splenic evaluation, multivariate analysis found an independent correlation between SU and splenic foci (p = 0.034). No statistical link was found between SU and inflammatory markers. Our study demonstrates that diffuse BMU at initial staging of HL could be due to bone marrow involvement but more likely to bone marrow inflammatory change and that diffuse SU in contrast is probably more associated with disease involvement than with inflammatory change.
引用
收藏
页码:1813 / 1821
页数:9
相关论文
共 50 条
[41]   Early interim 18F-FDG PET in Hodgkin’s lymphoma: evaluation on 304 patients [J].
Pier Luigi Zinzani ;
Luigi Rigacci ;
Vittorio Stefoni ;
Alessandro Broccoli ;
Benedetta Puccini ;
Antonio Castagnoli ;
Luca Vaggelli ;
Lucia Zanoni ;
Lisa Argnani ;
Michele Baccarani ;
Stefano Fanti .
European Journal of Nuclear Medicine and Molecular Imaging, 2012, 39 :4-12
[42]   Lymphoma Severity and Type Are Associated With Aortic FDG Uptake by 18F-FDG PET/CT Imaging [J].
Vlachopoulos, Charalambos V. ;
Koutagiar, Iosif P. ;
Georgakopoulos, Alexandros T. ;
Pouli, Anastasia G. ;
Sioni, Anastasia K. ;
Chondropoulos, Spiros D. ;
Solomou, Eirini G. ;
Terentes-Printzios, Dimitrios G. ;
Karakitsios, Ioannis G. ;
Kafouris, Pavlos P. ;
Gaitanis, Anastasios ;
Pianou, Nikoletta K. ;
Petrocheilou, Aikaterini ;
Aggeli, Constantina, I ;
Stroumpouli, Euaggelia ;
Marinakis, Theodoros P. ;
Voulgarelis, Michael ;
Tousoulis, Dimitrios M. ;
Anagnostopoulos, Constantinos D. .
JACC: CARDIOONCOLOGY, 2020, 2 (05) :758-770
[43]   Factors affecting intrapatient liver and mediastinal blood pool 18F-FDG standardized uptake value changes during ABVD chemotherapy in Hodgkin's lymphoma [J].
Chiaravalloti, Agostino ;
Danieli, Roberta ;
Abbatiello, Paolo ;
Di Pietro, Barbara ;
Travascio, Laura ;
Cantonetti, Maria ;
Guazzaroni, Manlio ;
Orlacchio, Antonio ;
Simonetti, Giovanni ;
Schillaci, Orazio .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (06) :1123-1132
[44]   Increased bone marrow uptake of 18F-FDG in leukemia patients: preliminary findings [J].
Arimoto, Maya Kato ;
Nakamoto, Yuji ;
Nakatani, Koya ;
Ishimori, Takayoshi ;
Yamashita, Kouhei ;
Takaori-Kondo, Akifumi ;
Togashi, Kaori .
SPRINGERPLUS, 2015, 4
[45]   18F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis [J].
Chowdhury, Mohammed M. ;
Tarkin, Jason M. ;
Evans, Nicholas R. ;
Le, Elizabeth ;
Warburton, Elizabeth A. ;
Hayes, Paul D. ;
Rudd, James H. F. ;
Coughlin, Patrick A. .
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2018, 56 (02) :172-179
[46]   Added Value of Baseline 18F-FDG Uptake in Serial 18F-FDG PET for Evaluation of Response of Solid Extracerebral Tumors to Systemic Cytotoxic Neoadjuvant Treatment: A Meta-Analysis [J].
van Ufford, Henriette M. E. Quarles ;
van Tinteren, Harm ;
Stroobants, Sigrid G. ;
Riphagen, Ingrid I. ;
Hoekstra, Otto S. .
JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (10) :1507-1516
[47]   The Diagnostic Value of 18F-FDG PET/CT Bone Marrow Uptake Pattern in Detecting Bone Marrow Involvement in Pediatric Neuroblastoma Patients [J].
Liu, Jun ;
Li, Cuicui ;
Yang, Xu ;
Lu, Xia ;
Zhang, Mingyu ;
Qian, Luodan ;
Wang, Wei ;
Kan, Ying ;
Yang, Jigang .
CONTRAST MEDIA & MOLECULAR IMAGING, 2022, 2022
[48]   18F-FDG PET-CT and trephine biopsy assessment of bone marrow involvement in lymphoma [J].
Ujjani, Chaitra S. ;
Hill, Elizabeth M. ;
Wang, Hongkun ;
Nassif, Samer ;
Esposito, Giuseppe ;
Ozdemirli, Metin ;
Cordova, Christine ;
Cheson, Bruce D. .
BRITISH JOURNAL OF HAEMATOLOGY, 2016, 174 (03) :410-416
[49]   Prognostic Value of Bone Marrow F-18 FDG Uptake in Patients with Advanced-Stage Diffuse Large B-Cell Lymphoma [J].
Wang, Jiyoung ;
Kim, Dongwoo ;
Kang, Won Jun ;
Cho, Hojin .
NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 54 (01) :28-34
[50]   18F-FDG PET/CT in primary non-Hodgkin's lymphoma of the sinonasal tract [J].
Tempescul, Adrian ;
Querellou, Solene ;
Ianotto, Jean-Christophe ;
Boisrame, Sylvie ;
Valette, Gerald ;
Berthou, Christian .
ANNALS OF HEMATOLOGY, 2010, 89 (06) :635-637