Acupuncture decreases neuropeptide Y expression in the hypothalamus of rats with streptozotocin-induced diabetes

被引：17
作者：
Lee, JD
Jang, MH
Kim, EH
Kim, CJ
机构：
[1] Kyung Hee Univ, Coll Oriental Med, Dept Acupuncture & Moxibust, Seoul, South Korea
[2] Semyung Univ, Coll Oriental med, Dept Meridianol, Jechon, South Korea
[3] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul, South Korea
来源：
ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH | 2004年 / 29卷 / 1-2期
关键词：
acupuncture; diabetes; immunohistochemistry; hypothalamus; neuropeptide Y; hyperphagia; streptozotocin;
D O I：
10.3727/036012904815901533
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
It has been known that acupuncture has various effects such as analgesia, promotion of homeostasis, improvements in brain circulation, and rectification of internal disorders. Neuropeptide Y (NPY), a 36-amino-acid peptide, is known to increase appetite. In the present study, the effect of acupuncture stimulation at Zusanli (St.36) on NPY expression in the Streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry., Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes. Needling on Zusanli resulted in decreased NPY levels in both the ARN and PVN of diabetic rats. The present study shows that acupuncture suppressed NPY expression in the ARN and PVN of the Hypothalamus in STZ-induced diabetic rats, suggesting the possibility that acupuncture treatment is effective in curbing the hyperphagia of diabetes.
引用
收藏
页码：73 / 82
页数：10
相关论文
共 33 条
[1]   RAPID AND LOCALIZED ALTERATIONS OF NEUROPEPTIDE-Y IN DISCRETE HYPOTHALAMIC NUCLEI WITH FEEDING STATUS [J].
BECK, B ;
JHANWARUNIYAL, M ;
BURLET, A ;
CHAPLEURCHATEAU, M ;
LEIBOWITZ, SF ;
BURLET, C .
BRAIN RESEARCH, 1990, 528 (02) :245-249
[2]   The poetry of Jane Austen and the Austen family [J].
Chandler, A .
ANQ-A QUARTERLY JOURNAL OF SHORT ARTICLES NOTES AND REVIEWS, 1999, 12 (02) :42-45
[3]   Nitric oxide in the gracile nucleus mediates depressor response to acupuncture (ST36) [J].
Chen, S ;
Ma, SX .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (02) :780-785
[4]   RETRACTED: New findings of the correlation between acupoints and corresponding brain cortices using functional MRI (Retracted Article. See vol 103, pg 10527, 2006) [J].
Cho, ZH ;
Chung, SC ;
Jones, JP ;
Park, JB ;
Park, HJ ;
Lee, HJ ;
Wong, EK ;
Min, BI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2670-2673
[5]   THE ANATOMY OF NEUROPEPTIDE-Y-CONTAINING NEURONS IN RAT-BRAIN [J].
CHRONWALL, BM ;
DIMAGGIO, DA ;
MASSARI, VJ ;
PICKEL, VM ;
RUGGIERO, DA ;
ODONOHUE, TL .
NEUROSCIENCE, 1985, 15 (04) :1159-1181
[6]  
CLEMENTJONES V, 1979, LANCET, V2, P380
[7]   Acute stress increases neuropeptide Y mRNA within the arcuate nucleus and hilus of the dentate gyrus [J].
Conrad, CD ;
McEwen, BS .
MOLECULAR BRAIN RESEARCH, 2000, 79 (1-2) :102-109
[8]   Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids [J].
Dryden, S ;
Burns, SJ ;
Frankish, HM ;
Williams, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 340 (2-3) :221-225
[9]  
FRANKISH HM, 1995, PEPTIDES, V16, P51
[10]   The effect of streptozotocin-induced diabetes on cell proliferation in the rat dentate gyrus [J].
Jackson-Guilford, J ;
Leander, JD ;
Nisenbaum, LK .
NEUROSCIENCE LETTERS, 2000, 293 (02) :91-94
1234