A convenient microwave-assisted arylstannane generation-Stille coupling protocol

被引：7

作者：

Dehlinger, Veronique ^{[1
]}

Cordier, Frederic ^{[1
]}

Dell, Colin P. ^{[1
]}

Dreyfus, Nicolas ^{[1
]}

Jenkins, Nikki ^{[1
]}

Sanderson, Adam J. ^{[1
]}

Smith, Colin W. ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Ctr, Windlesham GU20 6PH, Surrey, England

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 50期

关键词：

D O I：

10.1016/j.tetlet.2006.10.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient methodology for the synthesis of complex pyridin-3-yl-phenyl biaryl systems is described; microwave irradiation greatly enhances the rate of the two Pd-catalyzed key steps: formation of the stannane partner and its subsequent Stille coupling with a range of highly functionalized pyridines. Besides being fast and high yielding, this process also allows diversification of the pyridine at a late stage. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8973 / 8976

页数：4

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