Hepatobiliary Cancers, Version 2.2021

被引：653

作者：

Benson III, Al B. ^{[1
]}

D'Angelica, Michael I. ^{[2
]}

Abbott, Daniel E. ^{[3
]}

Anaya, Daniel A. ^{[4
]}

Anders, Robert ^{[5
]}

Are, Chandrakanth ^{[6
]}

Bachini, Melinda ^{[7
]}

Borad, Mitesh ^{[8
]}

Brown, Daniel ^{[9
]}

Burgoyne, Adam ^{[10
]}

Chahal, Prabhleen ^{[11
,12
]}

Chang, Daniel T. ^{[13
]}

Cloyd, Jordan ^{[14
,15
]}

Covey, Anne M. ^{[2
]}

Glazer, Evan S. ^{[16
]}

Goyal, Lipika ^{[17
]}

Hawkins, William G. ^{[18
,19
]}

Iyer, Renuka ^{[20
]}

Jacob, Rojymon ^{[21
]}

Kelley, R. Kate ^{[22
]}

Kim, Robin ^{[23
]}

Levine, Matthew ^{[24
]}

Palta, Manisha ^{[25
]}

Park, James O. ^{[26
]}

Raman, Steven ^{[27
]}

Reddy, Sanjay ^{[28
]}

Sahai, Vaibhav ^{[29
]}

Schefter, Tracey ^{[30
]}

Singh, Gagandeep ^{[31
]}

Stein, Stacey ^{[32
]}

Vauthey, Jean-Nicolas ^{[33
]}

Venook, Alan P. ^{[22
]}

Yopp, Adam ^{[34
]}

McMillian, Nicole R. ^{[35
]}

Hochstetler, Cindy ^{[35
]}

Darlow, Susan D. ^{[35
]}

机构：

[1] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Evanston, IL 60208 USA

[2] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[3] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[5] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[6] Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[7] Cholangiocarcinoma Fdn, Kearns, UT USA

[8] Mayo Clin, Ctr Canc, Rochester, MN USA

[9] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[10] UC San Diego Moores Canc Ctr, San Diego, CA USA

[11] Univ Hosp Seidman Canc Ctr, Case Comprehens Canc Ctr, Cleveland, OH USA

[12] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44106 USA

[13] Stanford Canc Inst, Stanford, CA USA

[14] Ohio State Univ, Comprehens Canc Ctr, James Canc Hosp, Columbus, OH 43210 USA

[15] Solove Res Inst, Columbus, OH USA

[16] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Knoxville, TN USA

[17] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[18] Barnes Jewish Hosp, Siteman Canc Ctr, St Louis, MO 63110 USA

[19] Washington Univ, Sch Med, St Louis, MO USA

[20] Roswell Park Comprehens Canc Ctr, Buffalo, NY USA

[21] ONeal Comprehens Canc Ctr UAB, Birmingham, AL USA

[22] UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[23] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA

[24] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[25] Duke Canc Inst, Durham, NC USA

[26] Fred Hutchinson Canc Res Ctr, Seattle Canc Care Alliance, 1124 Columbia St, Seattle, WA 98104 USA

[27] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA USA

[28] Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA

[29] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[30] Univ Colorado, Ctr Canc, Boulder, CO 80309 USA

[31] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[32] Smilow Canc Hosp, Yale Canc Ctr, New Haven, CT USA

[33] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[34] UT Southwestern Simmons Comprehens Canc Ctr, Dallas, TX USA

[35] Natl Comprehens Canc Network, Plymouth Meeting, PA USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2021年 / 19卷 / 05期

关键词：

UNRESECTABLE HEPATOCELLULAR-CARCINOMA; RANDOMIZED CONTROLLED-TRIAL; BODY RADIATION-THERAPY; PHASE-II TRIAL; DOXORUBICIN-ELUTING BEADS; PORTAL-VEIN EMBOLIZATION; CONVENTIONAL TRANSARTERIAL CHEMOEMBOLIZATION; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; PERCUTANEOUS RADIOFREQUENCY ABLATION; CLASSIFYING MICROVASCULAR INVASION;

D O I：

10.6004/jnccn.2021.0022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepa-tocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts (intrahepatic and extrahepatic cholangiocarcinoma). Due to the multiple modalities that can be used to treat the disease and the complications that can arise from comorbid liver dysfunction, a multidisciplinary evaluation is essential for determining an optimal treatment strategy. A multidisciplinary team should include hepatol-ogists, diagnostic radiologists, interventional radiologists, surgeons, medical oncologists, and pathologists with hepatobiliary cancer ex-pertise. In addition to surgery, transplant, and intra-arterial thera-pies, there have been great advances in the systemic treatment of HCC. Until recently, sorafenib was the only systemic therapy option for patients with advanced HCC. In 2020, the combination of atezo-lizumab and bevacizumab became the first regimen to show superi -or survival to sorafenib, gaining it FDA approval as a new frontline standard regimen for unresectable or metastatic HCC. This article discusses the NCCN Guidelines recommendations for HCC.

引用

页码：541 / 565

页数：25

共 259 条

[31] Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival [J].

Chang, Tammy T. ;

Sawhney, Rajiv ;

Monto, Alexander ;

Ben Davoren, J. ;

Kirkland, Jacob G. ;

Stewart, Lygia ;

Corvera, Carlos U. .

HPB, 2008, 10 (06) :405-411

[32] Measuring future liver remnant function prior to hepatectomy may guide the indication for portal vein occlusion and avoid posthepatectomy liver failure: a prospective interventional study [J].

Chapelle, Thiery ;

Op de Beeck, Bart ;

Roeyen, Geert ;

Bracke, Bart ;

Hartman, Vera ;

De Greef, Kathleen ;

Huyghe, Ivan ;

Van der Zijden, Thijs ;

Morrison, Stuart ;

Francque, Sven ;

Ysebaert, Dirk .

HPB, 2017, 19 (02) :108-117

[33] Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib: Patient-focused outcome results from the randomised phase III REACH study [J].

Chau, Ian ;

Peck-Radosavljevic, Markus ;

Borg, Christophe ;

Malfertheiner, Peter ;

Seitz, Jean Francois ;

Park, Joon Oh ;

Ryoo, Baek-Yeol ;

Yen, Chia-Jui ;

Kudo, Masatoshi ;

Poon, Ronnie ;

Pastorelli, Davide ;

Blanc, Jean-Frederic ;

Chung, Hyun Cheol ;

Baron, Ari D. ;

Okusaka, Takuji ;

Bowman, L. ;

Cui, Zhanglin Lin ;

Girvan, Allicia C. ;

Abada, Paolo B. ;

Yang, Ling ;

Zhu, Andrew X. .

EUROPEAN JOURNAL OF CANCER, 2017, 81 :17-25

[34] A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma [J].

Chen, MS ;

Li, JQ ;

Zheng, Y ;

Guo, RP ;

Liang, HH ;

Zhang, YQ ;

Lin, XJ ;

Lau, WY .

ANNALS OF SURGERY, 2006, 243 (03) :321-328

[35] Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial [J].

Cheng, Ann-Lii ;

Kang, Yoon-Koo ;

Chen, Zhendong ;

Tsao, Chao-Jung ;

Qin, Shukui ;

Kim, Jun Suk ;

Luo, Rongcheng ;

Feng, Jifeng ;

Ye, Shenglong ;

Yang, Tsai-Sheng ;

Xu, Jianming ;

Sun, Yan ;

Liang, Houjie ;

Liu, Jiwei ;

Wang, Jiejun ;

Tak, Won Young ;

Pan, Hongming ;

Burock, Karin ;

Zou, Jessie ;

Voliotis, Dimitris ;

Guan, Zhongzhen .

LANCET ONCOLOGY, 2009, 10 (01) :25-34

[36] Irreversible Electroporation for Unresectable Hepatocellular Carcinoma: Initial Experience and Review of Safety and Outcomes [J].

Cheung, W. ;

Kavnoudias, H. ;

Roberts, S. ;

Szkandera, B. ;

Kemp, W. ;

Thomson, K. R. .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2013, 12 (03) :233-241

[37] CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma. Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features [J].

Choi, Jin-Young ;

Lee, Jeong-Min ;

Sirlin, Claude B. .

RADIOLOGY, 2014, 273 (01) :30-50

[38] Impact of postoperative complications on long-term outcome of curative resection for hepatocellular carcinoma [J].

Chok, K. S. ;

Ng, K. K. ;

Poon, R. T. ;

Lo, C. M. ;

Fan, S. T. .

BRITISH JOURNAL OF SURGERY, 2009, 96 (01) :81-87

[39] Systematic review: the model for end-stage liver disease - should it replace Child-Pugh's classification for assessing prognosis in cirrhosis? [J].

Cholongitas, E ;

Papatheodoridis, GV ;

Vangeli, M ;

Terreni, N ;

Patch, D ;

Burroughs, AK .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2005, 22 (11-12) :1079-1089

[40] SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma [J].

Chow, Pierce K. H. ;

Gandhi, Mihir ;

Tan, Say-Beng ;

Khin, Maung Win ;

Khasbazar, Ariunaa ;

Ong, Janus ;

Choo, Su Pin ;

Cheow, Peng Chung ;

Chotipanich, Chanisa ;

Lim, Kieron ;

Lesmana, Laurentius A. ;

Manuaba, Tjakra W. ;

Yoong, Boon Koon ;

Raj, Aloysius ;

Law, Chiong Soon ;

Cua, Ian H. Y. ;

Lobo, Rolley R. ;

Teh, Catherine S. C. ;

Kim, Yun Hwan ;

Jong, Yun Won ;

Han, Ho-Seong ;

Bae, Si-Hyun ;

Yoon, Hyun-Ki ;

Lee, Rheun-Chuan ;

Hung, Chien-Fu ;

Peng, Cheng-Yuan ;

Liang, Po-Chin ;

Bartlett, Adam ;

Kok, Kenneth Y. Y. ;

Thng, Choon-Hua ;

Low, Albert Su-Chong ;

Goh, Anthony S. W. ;

Tay, Kiang Hiong ;

Lo, Richard H. G. ;

Goh, Brian K. P. ;

Ng, David C. E. ;

Lekurwale, Ganesh ;

Liew, Wei Ming ;

Gebski, Val ;

Mak, Kenneth S. W. ;

Soo, Khee Chee .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (19) :1913-+

← 1 2 3 4 5 6 7 8 9 10 →