Palladium-catalyzed cascade metallo-ene/Suzuki coupling reaction of allenamides

被引：34

作者：

Liang, Hanbing ^{[1
]}

Yan, Fachao ^{[1
]}

Dong, Xu ^{[1
]}

Liu, Qing ^{[1
]}

Wei, Xiaobing ^{[1
]}

Liu, Sheng ^{[2
]}

Dong, Yunhui ^{[1
]}

Liu, Hui ^{[1
,2
,3
]}

机构：

[1] Shandong Univ Technol, Sch Chem Engn, 266 West Xincun Rd, Zibo 255049, Peoples R China

[2] Zibo Entry & Exit Inspect & Quarantine Bur, Tech Ctr, Zibo 255031, Peoples R China

[3] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 21期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE CARBOCYCLIZATION-BORYLATION; PEPTIDASE-IV INHIBITOR; C BOND FORMATION; ENE REACTIONS; ARYLATING CARBOCYCLIZATION; CARBONYLATION-ALKYNYLATION; REGIOSELECTIVE SYNTHESIS; CYCLOISOMERIZATION; CYCLIZATION; 1,6-DIENES;

D O I：

10.1039/c7cc00191f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new type of cascade metallo-ene/Suzuki coupling reaction of allenamides catalyzed by palladium is described. A variety of polyfunctionalized 2,3-dihydropyrrole derivatives, which are important structural motifs for bioactive molecules, were furnished with excellent yields. Two new Csp(3)-Csp(2) bonds were constructed in one pot efficiently. The reductive elimination from p-allyl palladium complex presented excellent regioselectivity to the terminal C1 position. The unique terminal alkene was one of the most easily functionalized groups, providing these molecules with a potential transformation to much more complicated molecules.

引用

页码：3138 / 3141

页数：4

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