Deciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma

被引：3

作者：

Brennan, P. E. ^{[1
]}

机构：

[1] Univ Oxford, Struct Genom Consortium, Target Discovery Inst, Nuffield Dept Med, Oxford OX3 7FZ, England

来源：

CELL DEATH & DISEASE | 2016年 / 7卷

关键词：

PROTEIN-KINASE; 2; CHEMICAL PROBES; DISCOVERY;

D O I：

10.1038/cddis.2015.384

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：e2069 / e2069

页数：3

共 14 条

[1] Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) [J].

Anderson, David R. ;

Meyers, Marvin J. ;

Vernier, William F. ;

Mahoney, Matthew W. ;

Kurumbail, Ravi G. ;

Caspers, Nicole ;

Poda, Gennadiy I. ;

Schindler, John F. ;

Reitz, David B. ;

Mourey, Robert J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (11) :2647-2654

[2] The promise and peril of chemical probes [J].

Arrowsmith, Cheryl H. ;

Audia, James E. ;

Austin, Christopher ;

Baell, Jonathan ;

Bennett, Jonathan ;

Blagg, Julian ;

Bountra, Chas ;

Brennan, Paul E. ;

Brown, Peter J. ;

Bunnage, Mark E. ;

Buser-Doepner, Carolyn ;

Campbell, Robert M. ;

Carter, Adrian J. ;

Cohen, Philip ;

Copeland, Robert A. ;

Cravatt, Ben ;

Dahlin, Jayme L. ;

Dhanak, Dashyant ;

Edwards, Aled M. ;

Frye, Stephen V. ;

Gray, Nathanael ;

Grimshaw, Charles E. ;

Hepworth, David ;

Howe, Trevor ;

Huber, Kilian V. M. ;

Jin, Jian ;

Knapp, Stefan ;

Kotz, Joanne D. ;

Kruger, Ryan G. ;

Lowe, Derek ;

Mader, Mary M. ;

Marsden, Brian ;

Mueller-Fahrnow, Anke ;

Mueller, Susanne ;

O'Hagan, Ronan C. ;

Overington, John P. ;

Owen, Dafydd R. ;

Rosenberg, Saul H. ;

Roth, Brian ;

Ross, Ruth ;

Schapira, Matthieu ;

Schreiber, Stuart L. ;

Shoichet, Brian ;

Sundstrom, Michael ;

Superti-Furga, Giulio ;

Taunton, Jack ;

Toledo-Sherman, Leticia ;

Walpole, Chris ;

Walters, Michael A. ;

Willson, Timothy M. .

NATURE CHEMICAL BIOLOGY, 2015, 11 (08) :536-541

[3] Target validation using chemical probes [J].

Bunnage, Mark E. ;

Chekler, Eugene L. Piatnitski ;

Jones, Lyn H. .

NATURE CHEMICAL BIOLOGY, 2013, 9 (04) :195-199

[4] Dual kinase-bromodomain inhibitors for rationally designed polypharmacology [J].

Ciceri, Pietro ;

Mueller, Susanne ;

O'Mahony, Alison ;

Fedorov, Oleg ;

Filippakopoulos, Panagis ;

Hunt, Jeremy P. ;

Lasater, Elisabeth A. ;

Pallares, Gabriel ;

Picaud, Sarah ;

Wells, Christopher ;

Martin, Sarah ;

Wodicka, Lisa M. ;

Shah, Neil P. ;

Treiber, Daniel K. ;

Knapp, Stefan .

NATURE CHEMICAL BIOLOGY, 2014, 10 (04) :305-+

[5] Discovery and characterization of a substrate selective p38α inhibitor [J].

Davidson, W ;

Frego, L ;

Peet, GW ;

Kroe, RR ;

Labadia, ME ;

Lukas, SM ;

Snow, RJ ;

Jakes, S ;

Grygon, CA ;

Pargellis, C ;

Werneburg, BG .

BIOCHEMISTRY, 2004, 43 (37) :11658-11671

[6] Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays [J].

Dranchak, Patricia ;

MacArthur, Ryan ;

Guha, Rajarshi ;

Zuercher, William J. ;

Drewry, David H. ;

Auld, Douglas S. ;

Inglese, James .

PLOS ONE, 2013, 8 (03)

[7] Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2 [J].

Gurgis, F. M. S. ;

Akerfeld, M. C. ;

Heng, B. ;

Wong, C. ;

Adams, S. ;

Guillemin, G. J. ;

Johns, T. G. ;

Chircop, M. ;

Munoz, L. .

CELL DEATH DISCOVERY, 2015, 1

[8] Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation, and Cell Cycle: Role and Targeting [J].

Gurgis, Fadi Maged Shokry ;

Ziaziaris, William ;

Munoz, Lenka .

MOLECULAR PHARMACOLOGY, 2014, 85 (02) :345-356

[9] Cytotoxic Activity of Tivantinib (ARQ 197) Is Not Due Solely to c-MET Inhibition [J].

Katayama, Ryohei ;

Aoyama, Aki ;

Yamori, Takao ;

Qi, Jie ;

Oh-hara, Tomoko ;

Song, Youngchul ;

Engelman, Jeffrey A. ;

Fujita, Naoya .

CANCER RESEARCH, 2013, 73 (10) :3087-3096

[10] Comparing Immobilized Kinase Inhibitors and Covalent ATP Probes for Proteomic Profiling of Kinase Expression and Drug Selectivity [J].

Lemeer, Simone ;

Zoergiebel, Gonna ;

Ruprecht, Benjamin ;

Kohl, Kristian ;

Kuster, Bernhard .

JOURNAL OF PROTEOME RESEARCH, 2013, 12 (04) :1723-1731

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