Migration and invasion of cancer cells into surrounding tissue and vasculature is an important initial step in cancer metastasis. Metastasis is the leading cause of cancer related death and thus it is crucial that we improve our understanding of the mechanisms that promote this life-threatening phenomenon. Cell migration involves a complex, multistep process that leads to the actin-driven movement of cells on or through the tissues of the body. The multifunctional scaffolding protein RACK1 plays important roles in nucleating cell signalling hubs, anchoring proteins at specific subcellular locations and regulating protein activity. It is essential for cell migration and accumulating evidence now demonstrates multiple roles for RACK1 in regulating migration and invasion of tumour cells. The possibility of designing drugs that block the migratory and invasive capabilities of cancer cells represents an attractive therapeutic strategy for treating malignant disease with RACK1 being a potential target. In this review we summarize this evidence and examine the mechanisms that underlie the contribution of RACK1 to the various stages of cell migration and invasion. (C) 2017 Elsevier Inc. All rights reserved.
机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Deng, Biao
Fang, JiaQing
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Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Fang, JiaQing
Zhang, XiaoFei
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机构:
Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200040, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Zhang, XiaoFei
Qu, Lei
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机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Qu, Lei
Cao, ZhongWei
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Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gastroenterol, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Cao, ZhongWei
Wang, Bin
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Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
机构:
Inst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France
CNRS, URA 2582, F-74724 Paris 15, FranceInst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France
机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Deng, Biao
Fang, JiaQing
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Fang, JiaQing
Zhang, XiaoFei
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200040, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Zhang, XiaoFei
Qu, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Qu, Lei
Cao, ZhongWei
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gastroenterol, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
Cao, ZhongWei
Wang, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R ChinaShanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China
机构:
Inst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France
CNRS, URA 2582, F-74724 Paris 15, FranceInst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France