Roles for RACK1 in cancer cell migration and invasion

被引:142
作者
Duff, Deirdre [1 ]
Long, Aideen [1 ]
机构
[1] Trinity Coll Dublin, Trinity Translat Med Inst, Trinity Ctr Hlth Sci, St Jamess Hosp, Dublin 8, Ireland
关键词
RACK1; Cell migration; Invasion; Metastasis; Cancer; ACTIVATED C KINASE; FOCAL ADHESION KINASE; MESENCHYMAL TRANSITION; DOWN-REGULATION; POOR-PROGNOSIS; GROWTH; PROMOTES; RECEPTOR; PROTEIN; SRC;
D O I
10.1016/j.cellsig.2017.03.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Migration and invasion of cancer cells into surrounding tissue and vasculature is an important initial step in cancer metastasis. Metastasis is the leading cause of cancer related death and thus it is crucial that we improve our understanding of the mechanisms that promote this life-threatening phenomenon. Cell migration involves a complex, multistep process that leads to the actin-driven movement of cells on or through the tissues of the body. The multifunctional scaffolding protein RACK1 plays important roles in nucleating cell signalling hubs, anchoring proteins at specific subcellular locations and regulating protein activity. It is essential for cell migration and accumulating evidence now demonstrates multiple roles for RACK1 in regulating migration and invasion of tumour cells. The possibility of designing drugs that block the migratory and invasive capabilities of cancer cells represents an attractive therapeutic strategy for treating malignant disease with RACK1 being a potential target. In this review we summarize this evidence and examine the mechanisms that underlie the contribution of RACK1 to the various stages of cell migration and invasion. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:250 / 255
页数:6
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