A Multidisciplinary Approach to Prenatal Treatment of Congenital Long QT Syndrome

被引：5

作者：

Crimmins, Sarah ^{[1
]}

Vashit, Sudhir ^{[2
]}

Doyle, Lauren ^{[1
]}

Harman, Chris ^{[1
]}

Turan, Ozhan ^{[1
]}

Turan, Sifa ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Obstet, Ctr Adv Fetal Care, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Pediat, Baltimore, MD 21201 USA

来源：

JOURNAL OF CLINICAL ULTRASOUND | 2017年 / 45卷 / 03期

关键词：

hydrops; long QT; prenatal diagnosis; CARDIAC-ARRHYTHMIA; CHANNEL DYSFUNCTION; FETAL;

D O I：

10.1002/jcu.22386

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

A 27-week fetus evaluated for bradycardia and hydrops was found to have anti-SSA-negative 28 atrioventricular block and ventricular tachycardia. A presumptive diagnosis of fetal long QT syndrome was made. Transplacental pharmacotherapy with intravenous magnesium and lidocaine restored sinus rhythm. At 30 6/7 weeks, the infant was delivered due to premature labor. Despite postnatal treatment with mexiletine and propranolol, she developed torsades de pointes. Ultimately, a de novo KCNH2 G628S mutation was diagnosed. She received an implantable cardiac defibrillator at 5 months of age. Early diagnosis and a multidisciplinary approach allowed successful in utero treatment and anticipatory postnatal management. (C) 2016 Wiley Periodicals, Inc.

引用

页码：168 / 170

页数：3

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